Evidence map›Paper›PMID 41484585›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Kidney function monitoring in pediatric sickle cell disease: evidence from the NEPHRODREPA study.

Élise Larché, Joy Benadiba, Pierre Simon Rohrlich, Camille Faudeux, Etienne Bérard, Fabrice Monpoux, Caroline Grangeon, Carine Cerato-Blanc, Jennifer Battista, Marie Meyronnet and 5 more

Registry-linked trialAbstract read
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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05211037 (Screening for Renal Complications in Children and Young Adults With Major Sickle Cell Disease), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05211037 nacompletednot on this map

Screening for Renal Complications in Children and Young Adults With Major Sickle Cell Disease

TypeinterventionalSponsorCentre Hospitalier Universitaire de NiceRan2022 to 2024Enrolled18ConditionsAnemia, Sickle Cell DiseaseArmsKidney function assessment
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Élise LarchéService de Néphrologie Pédiatrique, CHU de Nice, Hôpital Archet, 151 Route Saint-Antoine de Ginestière, 06202, Nice, France.
Joy BenadibaService d'hématologie Pédiatrique, CHU de Nice, Hôpital Archet, 06202, Nice, France.
Pierre Simon RohrlichFaculté de Médecine, Université Côte d'Azur, 06107, Nice, France.
Camille FaudeuxService de Néphrologie Pédiatrique, CHU de Nice, Hôpital Archet, 151 Route Saint-Antoine de Ginestière, 06202, Nice, France.
Etienne BérardService de Néphrologie Pédiatrique, CHU de Nice, Hôpital Archet, 151 Route Saint-Antoine de Ginestière, 06202, Nice, France.
Fabrice MonpouxService d'hématologie Pédiatrique, CHU de Nice, Hôpital Archet, 06202, Nice, France.
Caroline GrangeonService de Médecine Nucléaire, CHU de Nice, Hôpital Archet, 06202, Nice, France.
Carine Cerato-BlancService d'hématologie Pédiatrique, CHU de Nice, Hôpital Archet, 06202, Nice, France.
Jennifer BattistaService de Néphrologie Pédiatrique, CHU de Nice, Hôpital Archet, 151 Route Saint-Antoine de Ginestière, 06202, Nice, France.
Marie MeyronnetService d'hématologie Pédiatrique, CHU de Nice, Hôpital Archet, 06202, Nice, France.
Jeanne BernatService d'hématologie Pédiatrique, CHU de Nice, Hôpital Archet, 06202, Nice, France.
Valeriia RezapovaFaculté de Médecine, Université Côte d'Azur, 06107, Nice, France.
Laurence Derain DubourgService de Néphrologie, Dialyse, Hypertension Et Exploration Fonctionnelle Rénale, Hospices Civils de Lyon, Hôpital E. Herriot, 69003, Lyon, France.
Claus Peter SchmittFaculty of Medicine Heidelberg, Department of Pediatrics I, Pediatric Nephrology, Heidelberg University, Heidelberg, Germany.
Julie BernardorService de Néphrologie Pédiatrique, CHU de Nice, Hôpital Archet, 151 Route Saint-Antoine de Ginestière, 06202, Nice, France. bernardor.j@chu-nice.fr.ORCID http://orcid.org/0000-0002-1356-1507

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSickle cell disease (SCD) induces early kidney abnormalities, beginning in childhood with glomerular hyperfiltration and progressing toward chronic kidney disease. Estimating glomerular filtration rate (GFR) in these patients remains challenging due to limitations of creatinine-based formulas. This study aimed to assess kidney function in children and young adults with SCD using isotopic GFR measurement and various estimation equations, including creatinine and cystatin C-based formulas.

methodsNEPHRODREPA is a prospective pilot study including 17 patients (age 4-21 years) followed at the University Hospital of Nice. In addition to the annual check-up, serum cystatin C and

resultsThe median GFR measured by

conclusionThis study suggests that in young patients with SCD without known nephropathy, the CKiDU25 equation using serum cystatin C, provides GFR estimates close to the gold standard isotopic measurement. Early tubular dysfunction is prevalent and may justify therapeutic interventions. These findings warrant confirmation in larger cohorts.

Indexed as

Anemia, Sickle CellGlomerular Filtration RateKidneyAdolescentBiomarkersChildChild, PreschoolCreatinineCystatin CFemaleHumansKidney Function TestsMalePilot ProjectsProspective StudiesTechnetium Tc 99m PentetateBiomarkersCreatinineCST3 protein, humanCystatin CTechnetium Tc 99m PentetateChildrenChronic kidney diseaseHyposthenuriaKidney functionSickle cell disease

Identifiers

PMID41484585

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.