Evidence map›Paper›PMID 41484982›Full record

ArticleBiomarker research2026

Histone modification-regulated LncRNA DLEU1 interacts with ASCC2/ALKBH3 complex to drive DNA repair, antioxidant homeostasis and glucose metabolism in gastric cancer.

Xiaoyan Zhang, Xin Wang, Qi Wang, Xu Wang, Hui Sun, Yingxue Liu, Cong Tan, Shujuan Ni, Weiwei Weng, Meng Zhang and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomarker research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Xiaoyan Zhang *Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Xin Wang *Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Qi Wang *Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Xu Wang *Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Hui SunDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Yingxue LiuDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Cong TanDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Shujuan NiDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Weiwei WengDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Meng ZhangDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Lei WangDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Dan HuangDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Jie ChenDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Xiaoyu WangLaboratory of Immunology and Virology, Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Lu GanDepartment of Medical Oncology, Fudan University Zhongshan Hospital, Shanghai, 200032, China.
Mierxiati AbudurexitiDepartment of Urology, Shanghai Pudong New Area Gongli Hospital, Shanghai, 200135, China.
Wenfeng WangDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. wangwenfeng1011@163.com.
Jinjia ChangDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. iamchangjinjia@163.com.
Weiqi ShengDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. shengweiqi2006@163.com.
Midie XuDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. xumd27202003@sina.com.

Funding

National Natural Science Foundation of China 82473011, 82273370, 82202899, 82172702Natural Science Foundation of Shanghai 22ZR1413000, 21ZR1414900Shanghai Municipal Health Commission Youth Projects 20214Y0394Shanghai Municipal Key Clinical Specialty shslczdzk01301Shanghai Science and technology development fund 19MC1911000Shanghai Science and Technology Innovation Action Plan Basic research project subproject 20JC1419303
6 · The paper itself

Abstract

backgroundLong non-coding RNA (lncRNA) DLEU1 has been implicated in tumorigenesis, yet its mechanistic role in gastric cancer (GC) remains elusive.

methodsWe investigated the epigenetic regulation and oncogenic function of DLEU1 in GC through chromatin immunoprecipitation, RNA-protein interaction assays, and functional analyses in organoids and xenograft models. The molecular mechanisms underlying DLEU1-mediated DNA repair and metabolic adaptation were elucidated using western blotting, quantitative RT-PCR, and luciferase reporter assays.

resultsDLEU1 was significantly upregulated in GC, driven by H3K27 acetylation and H3K4 methylation. Mechanistically, DLEU1 promoted DNA repair by facilitating ASCC2 nuclear translocation and its interaction with ALKBH3, thereby stabilizing E2F1 mRNA. In turn, E2F1 directly activated G6PD transcription, leading to enhanced NADPH production, redox homeostasis, and glucose metabolism. Functionally, co-targeting DLEU1 and ASCC2 synergized with G6PD inhibition, significantly impairing GC cells viability and tumor growth.

conclusionOur findings establish DLEU1 as a key oncogenic lncRNA in GC, orchestrating DNA repair, redox balance, and metabolic adaptation via the ASCC2-ALKBH3-E2F1-G6PD axis. Targeting this pathway may provide a promising therapeutic strategy for overcome GC chemoresistance.

Identifiers

PMID41484982
PMCPMC12764130

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.