Evidence map›Paper›PMID 41485016›Full record

ArticleTrials2026

Autologous atrial appendage micrografts transplanted during coronary artery bypass surgery: design of the AAMS2 randomized, double-blinded, and placebo-controlled trial.

Vilbert Sikorski, Annu Nummi, Aleksi Kuuva, Erika Wilkman, Helena Rajala, Juhani Stewart, Juhani Junttila, Kai Lindgren, Kari Kervinen, Kari Teittinen and 25 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05632432 (Autologous Atrial Appendage Micrografts Transplanted During Coronary Artery Bypass Surgery), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05632432 narecruitingnot on this map

Autologous Atrial Appendage Micrografts Transplanted During Coronary Artery Bypass Surgery: the AAMS2 Randomized, Double-blinded, and Placebo-controlled Trial

TypeinterventionalSponsorHospital District of Helsinki and UusimaaRan2024 to 2026Enrolled50ConditionsIschemic Heart Disease, Ischemic Cardiomyopathy, Heart Failure, Systolic, Heart Failure NYHA Class IIIArmsEpicardial AAMs-patch transplantation, RNA-stabilized whole blood sampling, Plasma sampling, Transthoracic echocardiography, Late-gadolinium enhancement cardiac magnetic resonance imaging (LGE-CMRI)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Vilbert SikorskiFaculty of Medicine, Department of Pharmacology, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-2896-7550
Annu NummiDepartment of Cardiothoracic Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, P.O. Box 340, Haartmaninkatu 4, Helsinki, FIN-00029, Finland.
Aleksi KuuvaEpiHeart Oy, Helsinki, Finland.
Erika WilkmanDepartment of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Helena RajalaDivision of Cardiology, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Juhani StewartDivision of Cardiology, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Juhani JunttilaDivision of Cardiology, Department of Internal Medicine, Oulu University Hospital, Oulu, Finland.
Kai LindgrenDivision of Cardiology, Department of Internal Medicine, Oulu University Hospital, Oulu, Finland.
Kari KervinenHeart Unit, Oulu University Hospital, Oulu, Finland.
Kari TeittinenDepartment of Cardiothoracic Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, P.O. Box 340, Haartmaninkatu 4, Helsinki, FIN-00029, Finland.
Katja KohonenDepartment of Cardiothoracic Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, P.O. Box 340, Haartmaninkatu 4, Helsinki, FIN-00029, Finland.
Kati OksaharjuDepartment of Cardiothoracic Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, P.O. Box 340, Haartmaninkatu 4, Helsinki, FIN-00029, Finland.
Marjo OkkonenResearch Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and University Hospital of Oulu, Oulu, Finland.
Miia HolmströmRadiology, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Miia LehtinenDepartment of Cardiothoracic Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, P.O. Box 340, Haartmaninkatu 4, Helsinki, FIN-00029, Finland.
Severi MulariFaculty of Medicine, Department of Pharmacology, University of Helsinki, Helsinki, Finland.
Panu TaskinenDepartment of Cardiothoracic Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland.
Piia SimonenDivision of Cardiology, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Päivi KarvonenResearch Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and University Hospital of Oulu, Oulu, Finland.
Päivi KastellResearch Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and University Hospital of Oulu, Oulu, Finland.
Päivi Kärjä-KoskenkariDivision of Cardiology, Department of Internal Medicine, Oulu University Hospital, Oulu, Finland.
Riina KandolinDivision of Cardiology, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Risto KesävuoriRadiology, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Sari KaarlenkaskiResearch Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and University Hospital of Oulu, Oulu, Finland.
Satu VaaraRadiology, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Sebastian DahlbackaDepartment of Cardiothoracic Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, P.O. Box 340, Haartmaninkatu 4, Helsinki, FIN-00029, Finland.
Simo SyrjäläDepartment of Cardiothoracic Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, P.O. Box 340, Haartmaninkatu 4, Helsinki, FIN-00029, Finland.
Suvi SyvärantaRadiology, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Tatu JuvonenDepartment of Cardiothoracic Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, P.O. Box 340, Haartmaninkatu 4, Helsinki, FIN-00029, Finland.
Tiina ErkinaroResearch Group of Anesthesiology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Tuomas MäkeläAnesthesia and Intensive Care, Research Unit of Surgery, University of Oulu and Medical Research Center, Oulu, Finland.
Pasi KarjalainenDivision of Cardiology, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Esko KankuriFaculty of Medicine, Department of Pharmacology, University of Helsinki, Helsinki, Finland.
Antti VentoDepartment of Cardiothoracic Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, P.O. Box 340, Haartmaninkatu 4, Helsinki, FIN-00029, Finland.
Antti NykänenDepartment of Cardiothoracic Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, P.O. Box 340, Haartmaninkatu 4, Helsinki, FIN-00029, Finland. antti.nykanen@hus.fi.

Funding

Aarne Koskelon Säätiö 2020Emil Aaltosen Säätiö 210212KGovernment-allocated block grants to specialty area TYH2021346Government-allocated block grants to specialty area TYH2023339Ida Montinin Säätiö 20210362Suomen Lääketieteen Säätiö 3857Sydäntutkimussäätiö 200174Sydäntutkimussäätiö 200196Wellcome Trust 220094
6 · The paper itself

Abstract

backgroundThe AAMS open-label clinical study demonstrated the safety and feasibility of epicardial transplantation of autologous right atrial appendage micrografts (AAMs) during coronary artery bypass grafting (CABG) surgery. The study also provided the first indications of therapeutic efficacy of the AAMs, as delivered within an extracellular matrix patch, to reduce ischemic scar and increase viable ventricular wall thickness. To further evaluate the initial beneficial effects observed in the AAMS study, we designed the randomized, double-blinded, and placebo-controlled AAMS2 trial. Focusing on patients with ischemic heart disease (IHD) and myocardial scar, the AAMS2 trial aims to generate state-of-the-art structural and functional imaging data of the myocardium treated with an AAMs-patch during CABG.

methodsThe AAMS2 trial recruits IHD patients who are set to undergo non-urgent CABG and present with an ischemic myocardial scar in preoperative cardiac magnetic resonance imaging (CMRI) with late gadolinium enhancement. Patients are randomized (1:1) to receive a collagen-based matrix patch (Hemopatch®), with or without AAMs, epicardially onto the scar border. The primary endpoint, assessed by CMRI preoperatively and at 6 months post-operative follow-up, focuses on the left ventricle scar mass. The secondary endpoints center on the change in scar mass by the AAMs-patch site and evaluation of therapy safety and feasibility as well as its effects on myocardial structure and function by echocardiography. Change in blood N-terminal-pro-BNP levels in the timeframe is the co-primary endpoint. DISCUSSION: Data from the AAMS2 trial provides the first randomized, blinded, and placebo-controlled evaluation of efficacy on epicardial AAMs transplantation for ischemic myocardial scar. This data will pave the road towards rational design of larger AAMs therapeutic efficacy-addressing trial(s).

trial registrationClinicalTrials.gov, NCT05632432, registered 30 November 2022, https://clinicaltrials.gov/study/NCT05632432 .

Indexed as

Atrial AppendageCicatrixCoronary Artery BypassCoronary Artery DiseaseMyocardial IschemiaDouble-Blind MethodFemaleHumansMagnetic Resonance ImagingMaleRandomized Controlled Trials as TopicTime FactorsTransplantation, AutologousTreatment OutcomeAAMs-patchAtrial appendageCardiac surgeryCell therapyEpitranscriptomicsHeart failureIschemic heart diseaseMicrograftsTissue-engineering

Identifiers

PMID41485016
PMCPMC12866517

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.