Evidence map›Paper›PMID 41485161›Full record

ReviewDiscover oncology2026

Exploring metabolic dynamics of cancer metastasis through in vitro models.

Ranae Lindeque, Christiaan F Labuschagne

Abstract readReview
In one paragraph

Review in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ranae LindequeBiomedical and Molecular Metabolism Research, North-West University, Potchefstroom, South Africa.ORCID https://orcid.org/0009-0001-2272-3117
Christiaan F LabuschagneBiomedical and Molecular Metabolism Research, North-West University, Potchefstroom, South Africa. stiaan.labuschagne@nwu.ac.za.ORCID https://orcid.org/0000-0001-9474-5174

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer metastasis, the leading cause of cancer related deaths, is closely associated with the dynamic metabolism and bioenergetics of these deadly cells. Unravelling how cancer cell metabolism changes during metastasis and what sets these cells apart from non-metastatic cells could potentially aid the development of future treatment options to terminally ill cancer patients. In vivo studies of the metastatic cascade from a metabolic point of view have been associated with various issues including difficulty in identifying the cells in various phases of the metastatic cascade, variable reproducibility, and small biomass of the identified cells. This could be addressed by adequate in vitro models where specific phases of metastasis can be modelled and studied in isolation, and sample biomass and metastasis specific parameters can be adapted to suit the researcher’s need. In this review we will assess the available models for studying metastasis in vitro, and their suitability for metabolomic studies.

Indexed as

3D cell cultureCancerIn vitro modelsMetabolomicsMetastasis

Identifiers

PMID41485161
PMCPMC12864566

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.