Evidence map›Paper›PMID 41486254›Full record

ArticleMagnetic resonance in medicine2026

Dynamic RBC-To-Membrane Ratio in

Gabriela María García Delgado, Ummul Afia Shammi, Cody Thornburgh, Mia Ruppel, Isabella Parks, Aaron Miller, John P Mugler, Talissa A Altes, Robert P Thomen

Abstract read
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In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gabriela María García DelgadoChemical and Biomedical Engineering, University of Missouri, Columbia, Missouri, USA.ORCID 0009-0003-6949-6454
Ummul Afia ShammiBiomedical Engineering, School of Engineering, University of Illinois, Chicago, Illinois, USA.
Cody ThornburghRadiology, School of Medicine, University of Missouri, Columbia, Missouri, USA.
Mia RuppelNeurology, School of Medicine, Washington University, St. Louis, Missouri, USA.
Isabella ParksChemical and Biomedical Engineering, University of Missouri, Columbia, Missouri, USA.
Aaron MillerPulmonary and Critical Care Medicine, School of Medicine, University of Missouri, Columbia, Missouri, USA.
John P MuglerRadiology and Medical Imaging, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Talissa A AltesRadiology, School of Medicine, University of Missouri, Columbia, Missouri, USA.
Robert P ThomenChemical and Biomedical Engineering, University of Missouri, Columbia, Missouri, USA.

Funding

NIH HHS R01-HL152288
6 · The paper itself

Abstract

purposeTo present a method for quantifying dissolved

methodsA spectroscopic sequence was performed in 45 subjects (27 healthy, 12 dyspnea of unknown origin [DUO], and 6 pulmonary hypertension [PH]) consisting of 499 pulse/acquire experiments. SVD was used to construct a low-noise approximation of FID data, and time-domain curve-fitting was performed on all free induction decays allowing calculation of RBC (218 ppm) and membrane (197 ppm) signal amplitudes and the RBC/membrane ratio. RBC/membrane oscillation amplitudes were assessed using independent t-tests. An Analysis of Covariance (ANCOVA) test was performed to control for age and sex, followed by post hoc Tukey tests for pairwise comparisons.

resultsIndependent t-tests demonstrated statistically significant differences in RBC oscillation amplitudes and RBC/membrane oscillation amplitudes among healthy subjects and DUO patients (p-value = 0.003 and p-value = 0.0008, respectively). An ANCOVA test was performed to control for age and sex and resulted in statistically significant differences among diseases (p = 3.12 × 10

conclusionDynamic RBC-to-membrane ratio measurements may yield useful physiological information related to overall lung health.

Indexed as

Erythrocyte MembraneErythrocytesHypertension, PulmonaryLungLung DiseasesMagnetic Resonance ImagingVascular DiseasesXenon IsotopesAdultAgedBiomarkersFemaleHumansMaleMiddle AgedBiomarkersXenon-129Xenon IsotopescardiopulmonarydissolvedhyperpolarizedlungsMRIxenon

Identifiers

PMID41486254
PMCPMC12962205

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.