Evidence map›Paper›PMID 41486305›Full record

ReviewNPJ precision oncology2026

The regulatory roles and therapeutic strategies of the solute carrier transporters in cancer metabolism.

Xiao Zhang, Jiao Feng, Xufan Cai, Weilang Xu, Tao Ding, Min He, Yonghui Dong, Xiaoling Xu, Zaiyuan Ye

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in NPJ precision oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiao ZhangSchool of Graduate, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Jiao FengKey Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Xufan CaiKey Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Weilang XuSchool of Graduate, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Tao DingSchool of Graduate, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Min HeSchool of Graduate, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Yonghui DongSchool of Graduate, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Xiaoling XuShulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang, China. ziyao1988@zju.edu.cn.
Zaiyuan YeKey Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China. zaiyuanye@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Solute Carrier (SLC) family regulates cancer metabolism, supporting proliferation and immune evasion. Key members, such as GLUT1, LAT1, ASCT2, xCT and MCT4, drive metabolic reprogramming and are therapeutic targets. Selective inhibitors like BAY-876 show preclinical efficacy. Combining SLC inhibition with standard therapies may overcome resistance, while personalized strategies and advances in biomarkers and drug delivery are critical for clinical translation.

Identifiers

PMID41486305
PMCPMC12804797

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.