Evidence map›Paper›PMID 41486557›Full record

ArticleACS chemical biology2026

A Gold-PROTAC Degrades the Oncogenic Tyrosine Kinase MERTK: Insights into the Degradome from a Steady-State System.

Sophie R Thomas, Thomas Iellici, Mihyun Park, Elisabeth Klaus, Andrea Bileck, Christopher Gerner, Samuel M Meier-Menches, Angela Casini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sophie R ThomasChair of Medicinal and Bioinorganic Chemistry, Department of Chemistry, School of Natural Sciences, Technical University of Munich, Lichtenbergstr. 4, 85748 Garching, Germany.ORCID 0000-0003-1110-430X
Thomas IelliciInstitute of Analytical Chemistry, University of Vienna, Waehringer Str. 38, 1090 Vienna, Austria.ORCID 0009-0004-7728-1418
Mihyun ParkChair of Medicinal and Bioinorganic Chemistry, Department of Chemistry, School of Natural Sciences, Technical University of Munich, Lichtenbergstr. 4, 85748 Garching, Germany.ORCID 0000-0002-3665-4247
Elisabeth KlausChair of Medicinal and Bioinorganic Chemistry, Department of Chemistry, School of Natural Sciences, Technical University of Munich, Lichtenbergstr. 4, 85748 Garching, Germany.
Andrea BileckInstitute of Analytical Chemistry, University of Vienna, Waehringer Str. 38, 1090 Vienna, Austria.ORCID 0000-0002-7053-8856
Christopher GernerInstitute of Analytical Chemistry, University of Vienna, Waehringer Str. 38, 1090 Vienna, Austria.ORCID 0000-0003-4964-0642
Samuel M Meier-MenchesInstitute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1090 Vienna, Austria.ORCID 0000-0002-8930-4574
Angela CasiniChair of Medicinal and Bioinorganic Chemistry, Department of Chemistry, School of Natural Sciences, Technical University of Munich, Lichtenbergstr. 4, 85748 Garching, Germany.ORCID 0000-0003-1599-9542

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proteolysis targeting chimeras (PROTACs) are bifunctional molecules designed to induce the degradation of specific proteins within a cell. While most PROTACs are noncovalent interactors, covalent PROTACs may benefit from improved selectivity and pharmacodynamics, yet remain largely understudied. Here, a covalent gold-based PROTAC (

Indexed as

c-Mer Tyrosine KinaseGoldProteolysisHL-60 CellsHumansThioredoxinsc-Mer Tyrosine KinaseGoldMERTK protein, humanThioredoxins

Identifiers

PMID41486557
PMCPMC12813982

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.