Evidence map›Paper›PMID 41486563›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A Natural Sweetener-inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals.

Longliang Qiao, Zhihao Wang, Shasha Tang, Yuan Fang, Guiling Yu, Xiaoting Qiu, Lingxue Niu, Tao Yan, Xingwan Liu, Xiaoding Ma and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Longliang QiaoDepartment of Breast Surgery, School of Medicine, Tongji Hospital, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0002-4480-1040
Zhihao WangShanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Shasha TangDepartment of Breast Surgery, School of Medicine, Tongji Hospital, Tongji University, Shanghai, China.
Yuan FangDepartment of Breast Surgery, School of Medicine, Tongji Hospital, Tongji University, Shanghai, China.
Guiling YuShanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Xiaoting QiuCollege of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, China.
Lingxue NiuShanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Tao YanShanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Xingwan LiuShanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Xiaoding MaShanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Deqiang KongShanghai Fengxian District Central Hospital, Shanghai, China.
Yang ZhouHealth Science Center, Wuhu Hospital, East China Normal University, Wuhu, China.
Ningzi GuanShanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Jinzhong TianShanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Meiyan WangShanghai 411 Hospital，China RongTong Medical Healthcare Group Co.Ltd. ，411 Hospital, School of Medicine, Shanghai University, Shanghai, China.
Haifeng YeShanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Fengfeng CaiDepartment of Breast Surgery, School of Medicine, Tongji Hospital, Tongji University, Shanghai, China.

Funding

National Natural Science Foundation of China 32171414National Natural Science Foundation of China 32250010：32261160373：32430064Natural Science Foundation of Chongqing CSTB2022NSCQ-MSX0461Natural Science Foundation of Shanghai 23ZR1419500Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0501300Postdoctoral Fellowship Program and China Postdoctoral Science Foundation 2025M772716Postdoctoral Fellowship Program and China Postdoctoral Science Foundation BX20250121Science and Technology Commission of Shanghai Municipality 23HC1410100：25HC2830300Sixth Cycle Key Discipline Funding from Tongji Hospital, Tongji University GJPY2337Sixth Cycle Key Discipline Funding from Tongji Hospital, Tongji University GJPY2402Sixth Cycle Key Discipline Funding from Tongji Hospital, Tongji University ZDTS24-RXYoung Scientists Fund of the National Natural Science Foundation of China 32401213Young Scientists Fund of the National Natural Science Foundation of China 3250120102
6 · The paper itself

Abstract

Cell-based therapies are recognized as the next generation living therapeutics in medicine, especially through the design of synthetic gene switches to enhance the safety and controllability of engineered cells. However, current small molecule-regulated synthetic gene switches face clinical limitations such as long-term side effects and metabolic disturbances. Here, we develop a natural sweetener psicose-inducible transgene expression (PURE) system based on the transcriptional repressor PsiR from Agrobacterium tumefaciens. We increase the induction sensitivity of PURE using computational docking to identify candidate PsiR mutations (PsiR

Indexed as

Sweetening AgentsAnimalsDiabetes Mellitus, Type 1Disease Models, AnimalHumansMiceObesitySweetening Agentscell‐based therapiesD‐Psicose colagene switchPURE system

Identifiers

PMID41486563
PMCPMC13042381

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.