Evidence map›Paper›PMID 41486887›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2-Mediated Ferroptosis and Apoptosis Inhibition and Exosome-Mediated Paracrine Signaling.

Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yiming PanDepartment of Orthopedics, State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Fengmei ZhangDepartment of Orthopedics, State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Jiayan ZhongDepartment of Orthopedics, State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Qian GongDepartment of Orthopedics, State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Nana GengDepartment of Orthopedics, State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Biao KuangDepartment of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Qiumei LanDepartment of Orthopedics, State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Miao YiDepartment of Orthopedics, State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Qiqi ZengDepartment of Orthopedics, State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Cheng ChenDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Mengtian FanDepartment of Orthopedics, State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Chunliang ZhaoState Key Laboratory of Ultrasound in Medicine and Engineering, Chongqing Medical University, Chongqing, China.
Deping ZengState Key Laboratory of Ultrasound in Medicine and Engineering, Chongqing Medical University, Chongqing, China.
Yu DuDepartment of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Mao NieDepartment of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Zhibiao WangState Key Laboratory of Ultrasound in Medicine and Engineering, Chongqing Medical University, Chongqing, China.
Fengjin GuoDepartment of Orthopedics, State Key Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical Sciences, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0009-0002-6975-6845

Funding

Chongqing Science and Technology Bureau Foundation (China) CSTB2023NSCQ-MSX0288Chongqing Science and Technology Bureau Foundation (China) CSTB2024NSCQMSX0243Chongqing Science and Technology Bureau Foundation (China) CSTB2024NSCQ-MSX0328CQMU Program for Youth Innovation in Future Medicine W0146Foundation of State Key Laboratory of Ultrasound in Medicine and Engineering 2024KFKT017National Natural Science Foundation of China 82202760National Natural Science Foundation of China 82272550National Natural Science Foundation of China 82472422
6 · The paper itself

Abstract

Circular RNAs (circRNAs) are covalently closed, stable non-coding RNAs that regulate diverse cellular processes. Here, we identify circTspan3 - derived from exons 2-6 of the Tspan3 gene - as a key regulator of cartilage development. The expression of circTspan3 is significantly downregulated in X-box binding protein 1 (Xbp1) conditional knockout (cKO) mice displaying chondrodysplasia and positively correlates with anabolic markers of cartilage. The XBP1 spliced (XBP1s) transcriptionally upregulates circTspan3, which in turn promotes anabolic activity in chondrocytes while suppressing both apoptosis and ferroptosis. Mechanistically, phosphorylation of ANNEXIN A2 (ANXA2) at Ser26 facilitates the cytoplasmic translocation of circTspan3, where ANXA2 mediates its packaging into exosomes for paracrine signalling. Exosomal circTspan3 enhances growth-plate expansion and effectively repairs cartilage defects in vivo. These findings highlight circTspan3 as a key modulator of growth-plate homeostasis and suggest its translational potential in treating cartilage injury and growth-associated skeletal disorders.

Indexed as

Annexin A2ApoptosisCartilageChondrogenesisExosomesFerroptosisParacrine CommunicationRNA, CircularAnimalsChondrocytesHumansMiceMice, KnockoutAnnexin A2RNA, CircularANXA2apoptosiscartilage developmentcircTspan3exosomesferroptosisP‐ANXA2 (Ser26)Xbp1s

Identifiers

PMID41486887
PMCPMC12915206

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.