Evidence map›Paper›PMID 41486901›Full record

ArticleRadiation oncology journal2025

Radiation therapy in a ductal carcinoma in situ patient with ornithine transcarbamylase deficiency: a case report.

Iris Kang, Justin Park, Christine Yang, Aster Kim, Mary Tang, Kaye Lu, Azadeh Carr, Stephen F Sener, Rachel McGowan, Shoji Yano and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiation oncology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Iris KangKeck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Justin ParkDepartment of Radiation Oncology, Los Angeles General Medical Center, Los Angeles, CA, USA.
Christine YangDepartment of Radiation Oncology, Los Angeles General Medical Center, Los Angeles, CA, USA.
Aster KimUniversity of California, Los Angeles, Los Angeles, CA, USA.
Mary TangPepperdine University, Pepperdine, CA, USA.
Kaye LuDepartment of Surgery, Los Angeles General Medical Center, Los Angeles, CA, USA.
Azadeh CarrDepartment of Surgery, Los Angeles General Medical Center, Los Angeles, CA, USA.
Stephen F SenerDepartment of Surgery, Los Angeles General Medical Center, Los Angeles, CA, USA.
Rachel McGowanGenetics Division, Department of Pediatrics, Los Angeles General Medical Center, Los Angeles, CA, USA.
Shoji YanoGenetics Division, Department of Internal Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Stella K YooDepartment of Radiation Oncology, Los Angeles General Medical Center, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ornithine transcarbamylase (OTC) deficiency is a rare urea cycle disorder that impairs ammonia detoxification, increasing the risk of hyperammonemic crises under metabolic stress. While chemotherapy-related risks have been reported, data on the safety of ionizing radiation therapy (RT) in this population are limited. This case describes a 30-year-old woman with late-onset OTC deficiency diagnosed with right-sided ductal carcinoma in situ. She underwent segmental mastectomy followed by adjuvant 3D conformal RT (40 Gy in 15 fractions with a concomitant boost to 48 Gy). Her multidisciplinary care involved preoperative hydration, close nutritional monitoring, and serial ammonia measurements. She completed RT without treatment interruptions or signs of hyperammonemia. This case illustrates that breast RT can be delivered safely in patients with OTC deficiency with a multidisciplinary, preventative approach. To our knowledge, this is the first report describing RT planning and metabolic surveillance in this population.

Indexed as

Breast neoplasmsCase reportsHyperammonemiaOrnithine carbamoyltransferase deficiency diseaseRadiotherapyUrea cycle disorders

Identifiers

PMID41486901
PMCPMC12770874

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.