ArticleCurrent Alzheimer research2026
Hypertension is the Main Vascular Risk Factor for Cognitive Impairment, Microvascular Pathology and Brain Atrophy in Alzheimer's Disease.
Article in Current Alzheimer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The Versatile Roles of Exosomes in Neurodegenerative Disorders: From Pathological Mechanism and Diagnostic Biomarkers to Therapeutic Application.Drug design, development and therapy · 2026Review
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Authors and funding
8 authors.
Funding
Abstract
introductionAlzheimer's Disease (AD) is the commonest pathology underlying dementia, but it frequently coexists with cerebrovascular disease (CVD). Existing literature supports a possible role for vascular risk factors (VRFs), including hypertension, diabetes and dyslipidaemia in AD pathogenesis. This study aims to determine whether VRFs contribute to typical AD pathogenesis or co-morbid CVD in mixed AD.
methodsWell-characterised probable AD subjects participating in two large clinical trials of Hydromethylthionine were classified into "typical AD" and "mixed" patterns based on FDG-PET images. VRFs, including hypertension, diabetes and dyslipidaemia, and MRI-derived White Matter Hyperintensities (WMHs) and brain fraction (as a measure of brain atrophy) were analysed to investigate the relationship between VRFs and AD subtypes.
resultsOf 794 participants, 533 (67.1%) were classified as typical AD and 261 (32.8%) were classified as mixed. Among VRFs, cardiovascular risks were significantly more frequent in typical AD (59%) than in mixed subtype (47%) (p = 0.002). DISCUSSION: We found that it was mainly hypertension that differed according to subtypes. Although brain atrophy is the main driver of cognitive impairment in patients with AD subtype, the microvascular pathology in the form of WMHs was significantly higher in patients with hypertension, irrespective of subtype.
conclusionAlthough hypertension is the main risk factor for cerebrovascular disease, contrary to our expectation, hypertension is common in typical AD than the mixed subtype, and this association is driven by the hitherto unsuspected contribution of microvascular pathology to cognitive impairment in typical AD.
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Registered trials
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