ReviewJournal of pain research2025
Modulating Gamma Oscillations in the Anterior Cingulate Cortex with Intermittent Theta Burst Stimulation: Implications for Chronic Non-Specific Low Back Pain.
Review in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Comparative Efficacy of Non-invasive Brain Stimulation for Pain, Anxiety, and Depression: A Systematic Review and Network Meta-analysis.Pain and therapy · 2026Review
- Postoperative pain evaluation in laparoscopic radical prostatectomy surgery using tranexamic acid: analgesia?, hyperalgesia??World journal of urology · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic nonspecific low back pain (CNSLBP), a debilitating condition associated with abnormal anterior cingulate cortex (ACC) activity and central sensitization, may be addressed through intermittent theta-burst stimulation (iTBS), a non-invasive neuromodulation technique. iTBS is designed to restore the ACC's excitatory/inhibitory balance by suppressing abnormal gamma oscillations and enhancing synaptic plasticity. Clinical evidence shows that iTBS can reduce ACC gamma power, strengthen corticostriatal circuit connectivity, and provide short-term pain relief, although efficacy varies with protocol, pain subtype, and individual differences. In conclusion, iTBS represents a promising approach for managing CNSLBP by modulating neuroplasticity. Future efforts should focus on optimizing stimulation parameters, integrating multimodal data for personalized treatment, and validating long-term benefits through large-scale trials to shift the therapeutic paradigm towards remodeling maladaptive neural pathways.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.