ReviewBiomaterial investigations in dentistry2025
Self-healing dental biomaterials: bioinspired pathways to sustainable dentistry.
Review in Biomaterial investigations in dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Resin composite restorations typically last 6-10 years but often fail due to mechanical fatigue, hydrolytic breakdown, and degradation at the interface. These failures result in frequent replacements, leading to significant clinical and environmental impacts. Extending restoration durability is essential for both patient care and sustainability. This review examines recent advances in self-healing dental biomaterials, emphasising the underlying chemical and physical mechanisms, their integration into resin composites, cements, and adhesives, and their relevance to sustainable restorative practice. Materials and methods: A narrative review methodology was employed to synthesise the current evidence. Studies on self-healing mechanisms, including extrinsic (capsule- or reservoir-based) and intrinsic (dynamic covalent, supramolecular, or shape-memory polymer) systems, were critically evaluated with emphasis on evidence relevant to dental resin composites, cements, and adhesives. Parallel insights from polymer and material sciences were included where dental-specific research was limited. Supplementary searches were conducted on Google Scholar for additional peer-reviewed articles, books, and preprints. Results: Experimental resin composites and cements incorporating microcapsule-based self-healing systems exhibited fracture toughness recovery between 65% and 77%, maintaining structural integrity after 6 months of water storage in deionised water at 37°C. Disulfide and Diels-Alder dynamic networks, though mostly investigated in polymer science, show potential for repeatable healing under mild triggers, while supramolecular hydrogen-bonding and bioactive fillers offer adaptive repair and remineralisation at adhesive interfaces. Self-healing strategies align with the four pillars of green dentistry, that is pollution prevention, water conservation, energy efficiency, and waste reduction by potentially halving procedural resource consumption through extended restoration lifespan. Conclusion: Self-healing biomaterials designed and developed in accordance with sustainability principles have the potential to transform restorative dentistry by facilitating autonomous repair, prolonging restoration lifespan, and minimising the environmental footprint through reduced material usage and clinical waste generation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.