Evidence map›Paper›PMID 41487474›Full record

ArticleFrontiers in veterinary science2025

Lymph food to improve canine atopic dermatitis: a randomized, double-blinded, controlled trial in dogs with standard-care treatment.

Carolina Frizzo-Ramos, Pavlos G Doulidis, Iwan Anton Burgener, Christa Horvath Ungerböck, Veronika Einspieler, Ulrike Weiser, Lucia Panakova, Franziska Roth-Walter

Abstract read
In one paragraph

Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carolina Frizzo-RamosDepartment of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.
Pavlos G DoulidisDepartment for Companion Animals and Horses, Clinical Unit of Small Animals Internal Medicine, Dermatology, University of Veterinary Medicine Vienna, Vienna, Austria.
Iwan Anton BurgenerDepartment for Companion Animals and Horses, Clinical Unit of Small Animals Internal Medicine, Dermatology, University of Veterinary Medicine Vienna, Vienna, Austria.
Christa Horvath UngerböckDepartment for Companion Animals and Horses, Clinical Unit of Small Animals Internal Medicine, Dermatology, University of Veterinary Medicine Vienna, Vienna, Austria.
Veronika EinspielerDepartment for Companion Animals and Horses, Clinical Unit of Small Animals Internal Medicine, Dermatology, University of Veterinary Medicine Vienna, Vienna, Austria.
Ulrike WeiserDepartment for Companion Animals and Horses, Clinical Unit of Small Animals Internal Medicine, Dermatology, University of Veterinary Medicine Vienna, Vienna, Austria.
Lucia PanakovaDepartment for Companion Animals and Horses, Clinical Unit of Small Animals Internal Medicine, Dermatology, University of Veterinary Medicine Vienna, Vienna, Austria.
Franziska Roth-WalterDepartment of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Micronutritional deficits are linked to increased morbidity and mortality. Canine atopic dermatitis (CAD) often presents with iron depletion and subclinical inflammation, despite their typical meat-based diets, suggesting widespread micronutritional malabsorption. This study aimed to determine if a complementary lymph food-enriched with whey protein, vitamins, minerals, and antioxidants, and designed to bypass mucosal malabsorption barriers-could improve CAD clinical signs and blood parameters. Animals: Thirty-eight dogs diagnosed with canine atopic dermatitis were included in the study. Methods: In a 112-day, double-blinded, randomized study, 38 CAD dogs daily received 10 g of either the active lymph food ( Results: The complementary lymph food was well-accepted by the dogs. The active feed group showed significantly greater reductions in both CADESI-4 scores (-55%) and PVAS scores (-1.8) compared to the placebo group (+26%, Conclusion: Lymphatic nutrient feeding significantly improved CAD symptoms, suggesting a causative role of nutritional deficiencies in driving skin inflammation. This study strongly suggests a beneficial role for targeted lymphatic nutrient delivery in CAD management.

Indexed as

CADESIcanine atopic dermatitisinflammationlymph foodmalabsorptionnutrient deficiencypruritusveterinary complementary feed

Identifiers

PMID41487474
PMCPMC12758410

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.