ArticleNeuropsychiatric disease and treatment2025
Antidepressant-Like Effects of Mongolian Medical Warm Acupuncture via Remodeling the Gut Microbiota-Metabolite-Barrier Axis in CUMS Rats.
Article in Neuropsychiatric disease and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Mongolian warm acupuncture improves colonic barrier function and immune responses via the TLR4/MyD88/NF-κB pathway in insomnia rats.IBRO neuroscience reports · 2026Article
- Developmental Programming of Drug Response: Microbiota as a Missing Dimension in Perinatal Drug Discovery.International journal of molecular sciences · 2026Review
- Does the Microbiota-Gut-Brain Axis Mediate the Antidepressant Effects of Acupuncture? A Structured Review of Preclinical and Clinical Evidence.Neuropsychiatric disease and treatment · 2026Review
- Acupuncture Modulation of the Microbiota-Gut-Brain Axis in Major Depressive Disorder: Integrative Mechanisms, Emerging Evidence, and Future Therapeutic Perspectives.Neuropsychiatric disease and treatment · 2026Review
- Central Neurobiological Mechanisms of Acupuncture in Post-Stroke Depression: Multi-Target and Network-Based Regulation.Neuropsychiatric disease and treatment · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
Objective: This study evaluated the antidepressant-like effects of Mongolian medical warm acupuncture (MMWA) in a chronic unpredictable mild stress (CUMS) model and examined its mechanistic involvement in the gut microbiota-metabolite-barrier axis, representing a novel multi-omics investigation of this traditional therapy. Methods: Control, CUMS, and MMWA rats (n = 9/group) were assessed using sucrose preference, open-field activity, and Morris water maze tasks. Gut microbiota, fecal metabolites, and intestinal barrier markers were measured by 16S rRNA sequencing, UPLC-MS/MS metabolomics, qRT-PCR, and Western blotting. Results: MMWA improved CUMS-induced deficits, increasing sucrose preference (p < 0.01), enhancing locomotor activity (p < 0.01), and reducing escape latency (p < 0.05). Treatment restored microbial diversity and increased beneficial short-chain fatty acid (SCFA)-producing genera, including Lactobacillus and Prevotella (p < 0.05). Metabolomic analysis showed recovery of key neuroactive metabolites such as taurine and arginine (adjusted p < 0.05). MMWA also enhanced intestinal barrier integrity by upregulating Occludin, TJP1/ZO-1, and Claudin-4 (p < 0.001). Associations across microbiota-metabolite pathways reflected coordinated restoration. Conclusion: MMWA alleviates depressive-like behaviors by reshaping gut microbiota, normalizing metabolic profiles, and strengthening the intestinal barrier. These findings support its potential as a complementary approach for depressive-like conditions and highlight a mechanistic link involving the microbiota-metabolite-barrier axis.
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