SynthesisFrontiers in oral health2025
Systematic review and meta-analysis on the effect of olive oil in the treatment of periodontal diseases.
Synthesis in Frontiers in oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/objectives: Periodontal diseases, which are highly inflammatory in nature, are very common throughout the world. In recent years, natural products have gained special attention as a complement to conventional therapy, and olive oil/ozonated olive oil (OLO/OzOLO), due to its anti-inflammatory and antimicrobial properties, has been proposed for these treatments. The aim of our study was to demonstrate its short-term clinical efficacy in periodontal treatment. Methods: This systematic review and meta-analysis was conducted in accordance with Cochrane guidelines, and searches were performed in PubMed, Embase, Cochrane Central, Scopus, and Web of Science (WOS) to identify eligible studies. Review Manager 5.4.1 and SPSS Statistics 30.0® were used to calculate standardized mean differences (SMD) and 95% confidence intervals (CI). The main outcomes assessed for periodontitis were probing depth (PPD), bleeding on probing (BoP), and clinical attachment level (CAL), and for gingivitis, plaque index (PI), gingival index (GI) and bleeding index (BI). Results: Twelve randomized clinical trials (RCTs) involving 456 subjects were included. In periodontitis, compared with controls, OLO/OzOLO improved BoP reduction in the medium term (8-12 weeks) [-0.66; 95% CI (-1.07 to -0.26); Conclusions: Despite limitations, OLO/OzOLO treatments result in short-term CAL gain and improved gingival parameters. Systematic Review Registration: doi: 10.37766/inplasy2025.10.0065, Identifier INPLASY 2025100065.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.