ReviewCureus2025
Cerebrospinal Fluid Autoantibody Profiles in Rheumatologic Disorders Affecting the Central Nervous System: A Systematic Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatologic disorders affecting the central nervous system (CNS) can cause significant neurological and psychiatric morbidity. Early detection of CNS involvement is essential to prevent irreversible damage. This study aims to systematically review cerebrospinal fluid (CSF) autoantibody profiles in rheumatologic disorders and evaluate their diagnostic, prognostic, and clinical relevance. A systematic review of PubMed, Embase, Scopus, and Cochrane Library was conducted up to October 2025. Studies reporting CSF autoantibodies in systemic lupus erythematosus (SLE), primary Sjögren's syndrome (pSS), neuromyelitis optica spectrum disorder (NMOSD), and rheumatoid arthritis (RA) with CNS involvement were included. Data on antibody type, clinical correlations, and prognostic significance were extracted and synthesized. Ten studies met the inclusion criteria. Anti-NR2 and anti-ribosomal P antibodies were associated with neuropsychiatric manifestations in SLE. Anti-SSA (Ro) indicated CNS involvement in pSS. CSF aquaporin-4 IgG correlated with active disease in NMOSD, while anti-cyclic citrullinated peptide antibodies were detected in RA-related meningitis. CSF autoantibodies reflected intrathecal immune activity and offered higher diagnostic specificity than serum measurements. CSF autoantibody profiling provides clinically relevant biomarkers for CNS involvement in rheumatologic disorders. Standardized, longitudinal studies are needed to develop predictive panels and guide personalized immunotherapy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.