SynthesisFrontiers in rehabilitation sciences2025
Multicomponent exercise interventions for cognitive function in patients with mild cognitive impairment: a summary of best evidence.
Synthesis in Frontiers in rehabilitation sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Adherence to Exercise Interventions in Patients with Mild Cognitive Impairment: A Systematic Review and Meta-analysis.International journal of behavioral medicine · 2026Pooled it
- Exercise intervention on sleep quality in Alzheimer's disease: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Four-Limb Coordinated Training and Neuroplasticity in Older Adults with Cognitive Frailty: Mechanisms and Clinical Evidence.Clinical interventions in aging · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: This review systematically analyzes and synthesizes evidence on multicomponent training interventions aimed at improving cognitive function in older adults with mild cognitive impairment (MCI). The goal is to inform clinical practice with actionable insights. Design: Best evidence summary. Methods: This review adhered to the 6S model to identify evidence, searching data sources from their inception to April 30, 2025. The process involved systematic screening, quality appraisal, and data extraction for evidence synthesis. Results: A total of 12 sources were included: one guideline, six systematic reviews, one expert consensus, three evidence summaries, and one meta-analysis. From these sources, 24 best-evidence statements were synthesized across six domains: (a) principles for developing multicomponent training prescriptions, (b) intervention effects, (c) exercise dosage and intensity, (d) safety monitoring and risk management, (e) outcome assessment methods, and (f) strategies for promoting implementation and adherence. Conclusion: The evidence suggests that healthcare professionals should tailor multicomponent training interventions to the individual needs and clinical contexts of older adults with MCI to effectively slow cognitive decline. Relevance to clinical practice: This synthesis provides an evidence-based framework for developing multicomponent training protocols for older adults with MCI, supporting targeted interventions that may mitigate cognitive deterioration. Summary: This evidence synthesis integrates 12 high-quality sources, generating 24 best practice recommendations across six critical domains, including prescription design, exercise dosage, and safety management, offering guidance for personalized clinical application. Systematic Review Registration: Identifier [ES20257822].
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.