ArticleFrontiers in medicine2025
Pregnancy outcomes in idiopathic inflammatory myopathies: a Portuguese multicentre study.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Introduction: Idiopathic inflammatory myopathies (IIM) are rare autoimmune diseases that may complicate pregnancy, but evidence remains scarce. Disease activity at conception and during gestation, together with autoantibody profiles, are considered major determinants of adverse pregnancy outcomes (APOs). Methods: We conducted a retrospective multicentre study of 12 pregnancies in 10 women with IIM followed at four Portuguese tertiary centers (2009-2025). Demographic, clinical, immunological, therapeutic, maternal, and perinatal data were collected from medical records. Disease activity was assessed by clinical features, laboratory data, modified skin Disease Activity Score, and Manual Muscle Testing-8. Results: Phenotypes included overlap myositis ( Discussion: In this cohort, APOs were frequent, particularly among pregnancies complicated by disease activity. Although remission at conception was common, it did not fully prevent flares or obstetric complications. Anti-Jo-1 positivity appeared to cluster among the more severe cases, suggesting potential clinical relevance for monitoring. Multidisciplinary care and preconception optimization remain essential. Larger multicentre registries will be crucial to improving understanding and management of pregnancy in IIM.
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