ArticleWorld journal of oncology2026
The Role and Mechanism of G Protein Subunit Alpha-15 in Colorectal Cancer: An Analysis of Two Hundred Eight Patient Samples and Public Datasets.
Article in World journal of oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Identification and validation of GNA15 as a novel diagnostic biomarker in ulcerative colitis.Journal of molecular histology · 2026Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Colorectal cancer (CRC) is a tumor with a relatively high incidence rate. The expression of G protein subunit α-15 (GNA15) in CRC and its specific role remain unclear. Methods: This study focused on both the diagnostic potential of GNA15 and its mechanistic role in CRC progression. Relevant expression data of CRC were obtained from global databases, and the expression differences of GNA15 in CRC tissues and non-cancerous tissues were analyzed after processing. Tissue microarrays of CRC samples and surrounding non-tumor tissues from 208 CRC patients at the Red Cross Hospital of Yulin City were collected and prepared. The expression level of GNA15 was scored after immunostaining with rabbit anti-human GNA15 antibody. Meanwhile, the Results: The analysis results from the database and the tissue microarrays from the Red Cross Hospital of Yulin City both indicated that GNA15 was significantly overexpressed in CRC tissues. The gene effect scores calculated after knocking out GNA15 showed that the gene effect scores of HCC56 and DLD1 cell lines were strongly negative. GSEA indicated that the differentially expressed genes were mainly concentrated in biological processes such as antigen-antibody binding, immunoglobulin complex, phagocytosis, antigen processing and presentation, cell adhesion molecules, T helper 17 (Th17) cell differentiation, and toll-like receptor signaling pathway. This study has limitations, including a single-center retrospective cohort design and lack of Conclusions: GNA15 is highly expressed in CRC and has certain diagnostic value. GNA15 may play a role in CRC through affecting the growth of cell lines such as HCC56, DLD1 and biological processes such as antigen-antibody binding, immunoglobulin complex, phagocytosis, antigen processing and presentation, cell adhesion molecules, Th17 cell differentiation, and toll-like receptor signaling pathway.
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