Evidence map›Paper›PMID 41488367›Full record

ArticleiScience2025

miR-219a-Robo1 axis acts as a conserved switch for slit-mediated commissural axon guidance.

Bhakti Khot, Harindi Suriyaarachchi, Tanushree Majumder, Anagaa Nathan, Q Richard Lu, Guofa Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bhakti KhotDepartment of Molecular, Cellular, and Developmental Biology, College of Natural Sciences and Mathematics, University of Toledo, M.S. 601, 2801 W. Bancroft St., Toledo, OH 43606, USA.
Harindi SuriyaarachchiDepartment of Molecular, Cellular, and Developmental Biology, College of Natural Sciences and Mathematics, University of Toledo, M.S. 601, 2801 W. Bancroft St., Toledo, OH 43606, USA.
Tanushree MajumderDepartment of Molecular, Cellular, and Developmental Biology, College of Natural Sciences and Mathematics, University of Toledo, M.S. 601, 2801 W. Bancroft St., Toledo, OH 43606, USA.
Anagaa NathanDepartment of Molecular, Cellular, and Developmental Biology, College of Natural Sciences and Mathematics, University of Toledo, M.S. 601, 2801 W. Bancroft St., Toledo, OH 43606, USA.
Q Richard LuDepartment of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Guofa LiuDepartment of Molecular, Cellular, and Developmental Biology, College of Natural Sciences and Mathematics, University of Toledo, M.S. 601, 2801 W. Bancroft St., Toledo, OH 43606, USA.

Funding

The Coordination of miRNAs in Axon GuidanceR15NS126957 · NINDS · UNIVERSITY OF TOLEDO · PI Guofa Liu · 2022 to 2022
$452k
NICHD NIH HHS R03 HD099272NINDS NIH HHS R15 NS126957
6 · The paper itself

Abstract

Vertebrate commissural axon (CA) projection and midline crossing require suppression of Slit responsiveness in precrossing axons and its upregulation in postcrossing axons. Differential expression of the Slit receptor Robo1-low in precrossing and high in postcrossing axons-modulates Slit sensitivity and regulates midline crossing. However, the underlying mechanisms controlling this remain unclear. This study demonstrates that the 3' untranslated region (UTR) of

Indexed as

Cellular neuroscienceDevelopmental biologyDevelopmental neuroscience

Identifiers

PMID41488367
PMCPMC12756576

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.