Evidence map›Paper›PMID 41489085›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Microgel-Based Hierarchical Porous Hydrogel Patch with Adhesion and Resilience for Myocardial Infarction.

Ziyang Liu, Leyan Xuan, Yingying Hou, Ting Xie, Jieting Li, Junjie Cai, Siyu Zhang, Yingling Miao, Ning Hou, Gen He and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ziyang LiuGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.
Leyan XuanGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.
Yingying HouGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.
Ting XieGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.
Jieting LiGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.
Junjie CaiGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.
Siyu ZhangGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.
Yingling MiaoGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.
Ning HouGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.
Gen HeGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.
Maobin XieThe Fourth Affiliated Hospital of Guangzhou Medical University School of Biomedical Engineering Guangzhou Medical University, Guangzhou, China.
Xiyong YuGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0003-4988-7338
Mingen XuSchool of Automation, Hangzhou Dianzi University, Hangzhou, China.
Guosheng TangGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0009-0009-2791-8448

Funding

National Key Research and Development Program of China 2022YFA1104600National Key Research and Development Program of China 2022YFE0209700National Key Research and Development Program of China J23112012National Natural Science Foundation of China 32201183
6 · The paper itself

Abstract

While there has been considerable success in the 3D bioprinting of hydrogel scaffolds for tissue engineering, the application of traditional centimeter-scale bulk hydrogels with a dense internal nanoscale network structure remains a particular challenge. Here, we present a microgel-based modular fabrication strategy to engineer programmable hierarchically porous microgel-based hydrogel patches (HPMPs). This strategy generates porous microgels with adjustable porosity and bio/cytocompatibility via gas-shearing microfluidics integrated with an aqueous two-phase system, exhibiting precise model structural fidelity, synergistic tissue adhesion, and architectural resilience. Additionally, the interconnected hierarchical porous structure of HPMP enables rapid formation of functional vascular networks in vitro. To demonstrate the broad biomedical applicability of our modular bioprinting platform, we implemented this strategy in myocardial infarction treatment. We successfully validated the application-driven requirements via iPSC-laden porous microgels directing cardiomyocyte differentiation and functional maturity. HPMP with Janus-structured unilateral adhesiveness is conducive to preventing chest adhesions and cellular unilateral proliferation, migration, and angiogenesis in vivo. This microgel-based modular fabrication strategy establishes a promising platform for targeted cardiac repair, further promoting the development of tissue engineering and regenerative medicine.

Indexed as

HydrogelsMicrogelsMyocardial InfarctionTissue EngineeringTissue ScaffoldsAnimalsBioprintingCell AdhesionHumansMiceMyocytes, CardiacPorosityHydrogelsMicrogels3D bioprintingmicrogelmodular fabricationmyocardial infarctionporous hydrogel

Identifiers

PMID41489085
PMCPMC13042884

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.