ArticleEuropean archives of psychiatry and clinical neuroscience2026
Causal association between lipid profile and mental disorders: evidence from a bidirectional Mendelian randomization study.
Article in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundObservational studies have indicated interplay between lipid profiles and mental disorders, but genetic causal evidence remains limited. This study aimed to assess bidirectional causal links between lipid profiles and five major mental disorders using Mendelian randomization (MR) analysis.
methodsWe performed a bidirectional two-sample MR analysis utilizing genome-wide association study (GWAS) summary statistics from European populations. Genetic instruments were selected for five psychiatric disorders (major depressive disorder (MDD), anxiety, attention-deficit/hyperactivity disorder (ADHD), bipolar disorder (BIP), and schizophrenia (SCZ)) and six lipid traits: triglycerides (TG), total cholesterol (TC), high-/low-density lipoprotein cholesterol (HDL/LDL) and apolipoproteins (Apo A-1, Apo B). The inverse-variance weighted (IVW) method served as the primary analytical approach, complemented by MR-Egger regression to evaluate horizontal pleiotropy.
resultsForward MR analysis suggested a significant causal relationship between LDL and MDD (p
conclusionsThese findings suggest that genetically predicted TG levels may influence anxiety risk, while genetic predisposition to MDD and ADHD may contribute to dyslipidemia. Our study provides genetic evidence supporting a potential causal interplay between lipid metabolism and mental disorders, highlighting the need for interdisciplinary care and personalized monitoring to address psycho-metabolic comorbidities.
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