Evidence map›Paper›PMID 41489643›Full record

ArticleMikrochimica acta2026

Label-free electrochemiluminescence aptasensing platform: Au-LDH-C

Wenwen Liu, Zhuang Zhang, Man Qi, Wenyu Wu, Jianzhi Sun, Zhen Li, Zhigang Wang

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenwen LiuShandong Provincial Key Laboratory of Monocrystalline Silicon Semiconductor Materials and Technology, College of Chemistry and Chemical Engineering, Dezhou University, Dezhou, 253023, China. liuwenwen0316@163.com.
Zhuang ZhangBeijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Man QiShandong Provincial Key Laboratory of Monocrystalline Silicon Semiconductor Materials and Technology, College of Chemistry and Chemical Engineering, Dezhou University, Dezhou, 253023, China.
Wenyu WuShandong Provincial Key Laboratory of Monocrystalline Silicon Semiconductor Materials and Technology, College of Chemistry and Chemical Engineering, Dezhou University, Dezhou, 253023, China.
Jianzhi SunShandong Provincial Key Laboratory of Monocrystalline Silicon Semiconductor Materials and Technology, College of Chemistry and Chemical Engineering, Dezhou University, Dezhou, 253023, China.
Zhen LiSchool of Physics and Electronics, Shandong Normal University, Jinan, 250014, China.
Zhigang WangShandong Provincial Key Laboratory of Monocrystalline Silicon Semiconductor Materials and Technology, College of Chemistry and Chemical Engineering, Dezhou University, Dezhou, 253023, China. wangzhigang158@163.com.

Funding

Experimental Techniques of Dezhou University SYJS24005Key Project of Undergraduate Teaching Reform Research in Shandong Province Z2023188Key projects of Natural Science Foundation of Shandong Province ZR2020KB014Scientific Research Foundation of Dezhou University 2022xjrc415, 2022xjrc447 and 2024xjrc129
6 · The paper itself

Abstract

Carcinoembryonic antigen (CEA), a crucial non-specific tumor biomarker, exhibited a normal serum level of 2.5-5.0 ng/mL in healthy individuals. Elevations beyond this range signify increased tumor risk, underscoring the critical need for early biomarker detection. This study developed an inhibited electrochemiluminescence (ECL) aptasensor for ultrasensitive CEA detection, leveraging an Au-LDH-C3N4 composite as both the luminophore and sensing platform. The synthesis of Au-LDH- C3N4 involved the initial preparation of C3N4 by thermal pyrolysis of melamine, the subsequent in-situ growth of cobalt-iron layered double hydroxide (LDH) to form LDH-C3N4, and the final in-situ deposition of Au NPs. The resulting Au-LDH-C3N4 nanocomposite integrated the advantages of its components: the LDH-C3N4 heterojunction enhanced ECL stability and charge separation, oxygen vacancies promoted the generation of sulfate radicals (SO4·⁻), and Au NPs improved electron transfer. Leveraging these synergistic effects, a label-free ECL sensing platform was constructed. The design of the nucleic acid probes using a complementary single-stranded DNA as a stable anchor and a specific aptamer for target recognition-ensured effective surface immobilization and high recognition specificity. The fabricated aptasensor achieved remarkable performance for CEA detection, featuring an extensive linear range (0.001 to 20 ng/mL) and an exceptionally low detection limit (0.3 pg/mL based on 3σ/S). In addition, the prepared aptasensor was successfully applied to serum analysis resulting in satisfactory results. This work presented the development of Au-LDH-C3N4-based ECL aptasensors and established an effective strategy for early detection of CEA.

Indexed as

Aptamers, NucleotideBiosensing TechniquesCarcinoembryonic AntigenElectrochemical TechniquesNanocompositesGoldGraphiteHumansHydroxidesLimit of DetectionLuminescent MeasurementsMetal NanoparticlesNitrilesNitrogen CompoundsAptamers, NucleotideCarcinoembryonic AntigencyanogenGoldGraphitegraphitic carbon nitrideHydroxidesNitrilesNitrogen CompoundsAptasensorAu-LDH-C3N4Carcinoembryonic antigenElectrochemiluminescenceGraphitic carbon nitrideLayered double hydroxide

Identifiers

PMID41489643

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.