Evidence map›Paper›PMID 41489787›Full record

ReviewJournal of assisted reproduction and genetics2026

The spermatozoon neck role in infertility and intracytoplasmic sperm injection outcomes.

Derek F Kluczynski, Isabel Nester, Haley Prine, Kadyn Heising, Ethan Gartee, David Adegoke, Gunnar Eriksen, Conner Liber, Yashwanth Byreddy, Rudraksh Dua and 7 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Derek F KluczynskiDepartment of Molecular, Cellular, and Developmental Biology, University of Toledo, Toledo, USA.
Isabel NesterDepartment of Molecular, Cellular, and Developmental Biology, University of Toledo, Toledo, USA.
Haley PrineDepartment of Molecular, Cellular, and Developmental Biology, University of Toledo, Toledo, USA.
Kadyn HeisingDepartment of Molecular, Cellular, and Developmental Biology, University of Toledo, Toledo, USA.
Ethan GarteeDepartment of Molecular, Cellular, and Developmental Biology, University of Toledo, Toledo, USA.
David AdegokeDepartment of Molecular, Cellular, and Developmental Biology, University of Toledo, Toledo, USA.
Gunnar EriksenDepartment of Molecular, Cellular, and Developmental Biology, University of Toledo, Toledo, USA.
Conner LiberDepartment of Molecular, Cellular, and Developmental Biology, University of Toledo, Toledo, USA.
Yashwanth ByreddyDepartment of Molecular, Cellular, and Developmental Biology, University of Toledo, Toledo, USA.
Rudraksh DuaDepartment of Molecular, Cellular, and Developmental Biology, University of Toledo, Toledo, USA.
Mira AdkinsDepartment of Molecular, Cellular, and Developmental Biology, University of Toledo, Toledo, USA.
Nathan PanDepartment of Molecular, Cellular, and Developmental Biology, University of Toledo, Toledo, USA.
Brady ArtzDepartment of Molecular, Cellular, and Developmental Biology, University of Toledo, Toledo, USA.
Natalie DoumetDepartment of Molecular, Cellular, and Developmental Biology, University of Toledo, Toledo, USA.
Haley SalazarDepartment of Molecular, Cellular, and Developmental Biology, University of Toledo, Toledo, USA.
Jakya WarrenDepartment of Molecular, Cellular, and Developmental Biology, University of Toledo, Toledo, USA.
Tomer Avidor-ReissDepartment of Molecular, Cellular, and Developmental Biology, University of Toledo, Toledo, USA. Tomer.AvidorReiss@utoledo.edu.

Funding

The Role of Rabbit POC1B inSperm CentriolesR15HD110863 · NICHD · UNIVERSITY OF TOLEDO · PI AVIDOR-REISS, TOMER · 2023 to 2023
$452k
Eunice Kennedy Shriver National Institute of Child Health and Human Development R15HD110863NICHD NIH HHS R15 HD110863
6 · The paper itself

Abstract

The mammalian spermatozoon neck is a unique structure that functions during spermatid differentiation and spermatozoa swimming, and its contents are critical for post-fertilization embryogenesis. Mutations in proteins localizing to the neck connecting piece (the modified pericentriolar material) result in acephalic spermatozoa. In contrast, mutations in proteins localizing to the centriole often produce abnormal tail morphology. Acephalic spermatozoa can be categorized based on the exact location of the neck breakpoint. Here, we classify 24 proteins known to cause acephaly in human and mice spermatozoa into five different acephalic types, depending on where the breakpoint occurs. We also discuss other proteins found in the spermatozoon neck, which may result in spermatozoa acephaly. The relationship between the exact location of the neck's break and intracytoplasmic sperm injection (ICSI) outcomes is explored in the context of the spermatozoon centrosome's role. We conclude that to understand this relationship, future research should investigate DNA, phospholipase C zeta, and centriole functionality, in addition to the location of the acephalic breakpoint in the patient's sperm.

Indexed as

Infertility, MaleSpermatozoaSperm Injections, IntracytoplasmicAnimalsCentriolesHumansMaleMiceSperm TailAcephalic spermatozoaCentrioleInfertilityIntracytoplasmic sperm injectionSpermatozoa neck

Identifiers

PMID41489787
PMCPMC12901780

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.