ArticleJournal of endocrinological investigation2026
Oxidized metabolites of linoleic acid as biomarkers of pancreatic beta-cell function in the first-onset type 2 diabetic patients with obesity.
Article in Journal of endocrinological investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesThe role of oxylipins in type 2 diabetes (T2D) with obesity remains poorly understood. This study aimed to characterize oxylipin profiles in T2D patients with obesity, identify associations with pancreatic beta-cell function, and suggest potential therapeutic targets.
methodsWe recruited first-onset T2D patients with obesity (OB group, n = 15) and normal-weight T2D patients (NW group, n = 15), matched by gender, age, and blood lipid levels. Serum samples were collected in a fasting state before medication. Oxylipin profiling was analyzed using liquid chromatography-tandem mass spectrometry, detecting 120 oxylipins. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were used to analyze oxylipin profiles, and Pearson’s correlation coefficients assessed the relationship between oxylipin concentrations and clinical parameters.
resultsSix oxylipins with variable importance in projection (VIP > 1) and p < 0.05 were significantly different between OB and NW groups. Five oxylipins (13-oxoODE, 12,13-EpOME, 15-keto-PGE2, 9,10-EpOME, 16(17)-EpDPE) were elevated in the OB group, while 2,3-dinor-8-iso-PGF2α was reduced. Correlation analysis revealed that 13-oxoODE, 15-keto-PGE2, and 16(17)-EpDPE levels positively correlated with BMI, visceral adipose tissue (VAT), and pancreatic beta-cell function.
conclusionsOxylipin profiling in first-onset T2D patients with obesity revealed that altered oxylipin metabolism, particularly linoleic acid pathways, is closely linked to pancreatic beta-cell dysfunction. These findings suggest potential biomarkers for therapeutic intervention.
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