ArticleJournal of the American Chemical Society2026
Asymmetric C-H Functionalization of Bicyclo[2.1.1]hexanes and Their 2-Oxa- and 2-Aza Derivatives via Rhodium Carbene Intermediates.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Interpreting terminal selectivity in undirected C(spChemical science · 2026Review
- Enantioselective Synthesis of Axially Chiral Spiro[3.3]heptanes by Site-Selective C-H Functionalization.ACS catalysis · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Bicyclo[2.1.1]hexanes have generated considerable interest in recent years as bioisosteres of benzene. In this article, a C-H functionalization approach is described to derivatize the bicyclo[2.1.1]hexanes. The approach relies on dirhodium-catalyzed C-H insertion by donor/acceptor carbenes, which proceeds in a highly diastereoselective and enantioselective manner. By the appropriate choice of substrates, the reaction can also be highly site-selective. The bicyclo[2.1.1]hexane is a difficult system for C-H functionalization via carbene intermediates because it is a strained molecule, which causes the C-H bonds to be stronger than in an unstrained system. The only catalyst that performed well in this transformation is the newly developed D
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.