ArticleOsteoarthritis and cartilage2026
Synovial fibroblast responses to different types of injury resulting in cartilage repair or osteoarthritis.
Article in Osteoarthritis and cartilage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Wnt/β-catenin signaling regulates fibrotic atrophy of intra-articular adipose tissue in post-traumatic osteoarthritis.bioRxiv : the preprint server for biology · 2026Article
- Association between cellular characteristics and clinical outcomes following autologous micro-fragmented adipose tissue injection for knee osteoarthritis.Frontiers in bioengineering and biotechnology · 2026Article
- Targeting subchondral osteoporosis in osteoarthritis: biomechanical crosstalk and the therapeutic rationale for inflammatory microenvironment remodeling.Frontiers in immunology · 2026Review
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5 authors.
Funding
Abstract
objectiveSingle-cell RNA-sequencing (scRNA-seq) has advanced our understanding of the heterogeneity of synovial fibroblasts and their roles in tissue repair and osteoarthritis. Here, we compared the fibroblast responses to different types and duration of joint injury in mice.
designPublished scRNA-seq data of synovial fibroblasts from a model of joint surface injury (JSI, day 6) and two post-traumatic osteoarthritis models, destabilisation of the medial meniscus (DMM, day 7 and 2 months) and anterior cruciate ligament rupture (ACLR, day 7 and day 28), were integrated and analysed using clustering, DEG, gene-set enrichment, regulon, pseudotime trajectory and cell-cycle analyses.
resultsThe response to JSI was comparatively dominated by lining progenitor and fibroblast-like synoviocyte (FLS) expansion, while DMM and ACLR induced transient expansion of perturbed-state fibroblasts (PSF) containing a myofibroblast subset, followed by FLS expansion over time. Early injury responses were underpinned by proliferating cells that directly supplied new PSF and FLS. Molecular pathway analysis revealed rapid and sustained injury-induced transcriptomic shifts in both lining and sublining fibroblasts, with post-traumatic OA models in particular showing marked upregulation of matrix-related genes indicative of myofibroblast activity and tissue remodeling. Activity of regulons associated with the PSF response, including Hes6, Hif1α, Zfp354c, Runx1 and Foxp1, showed model and stage-dependent upregulation. Finally, co-expression of lineage-specifying transcription factors Sox9, Runx2 and Scx, indicative of multilineage potential, was a common feature of PSF in all injury models.
conclusionsThis study uncovers similarities and differences in synovial fibroblast responses between injury models, guiding future research on joint repair and osteoarthritis.
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