Evidence map›Paper›PMID 41490883›Full record

ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2026

[Endogenous neddylation in B cells regulates immune responses in mice].

Xin Jin, Luyao Zhu, Lizhi Zhang, Tianhang Chen, Mingqian Zhou

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xin JinCollege of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China. zyyjinxin@163.com.
Luyao ZhuSchool of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Lizhi ZhangSchool of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Tianhang ChenCollege of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Mingqian ZhouCollege of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China. zhoumingqian@zcmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the regulatory role of endogenous neddylation in B cell-mediated immune responses.

methodsB cell-specific

resultsCompared with controls,

conclusionsEndogenous neddylation deficiency in B cells broadly impairs immune responses to both thymus-independent and thymus-dependent antigens in mice, and its regulatory effects are antigen-dependent.

Indexed as

B-LymphocytesUbiquitin-Conjugating EnzymesAnimalsMiceMice, Inbred C57BLMice, KnockoutUbiquitin-Conjugating EnzymesB lymphocyteMiceNeddylationThymus dependent antigenThymus independent antigenUbe2m

Identifiers

PMID41490883
PMCPMC13154130

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.