Evidence mapPaperPMID 41490933Full record

ReviewJournal of perinatology : official journal of the California Perinatal Association2026

Toward precision for bronchopulmonary dysplasia: Moving past current definitions.

Matthew J Kielt, Timothy D Nelin, Steven H Abman, Leif D Nelin

Abstract readReview
In one paragraph

Review in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matthew J KieltComprehensive Center for Bronchopulmonary Dysplasia, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-4568-9070
Timothy D NelinDivision of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-7435-2610
Steven H AbmanSection of Pulmonary and Sleep Medicine and the Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado Anschutz Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-7292-2085
Leif D NelinComprehensive Center for Bronchopulmonary Dysplasia, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH, USA. Leif.nelin@nationwidechildrens.org.ORCID http://orcid.org/0000-0002-3722-3035

Funding

Translational Research Support CoreP30ES013508 · UNIVERSITY OF PENNSYLVANIA · 2025 to 2025
$1.6M
Multidisciplinary Training Program in Pediatric Lung DiseasesT32HL160493 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · 2022 to 2025
$855k
Lung Injury Biomarkers to Endotype Respiratory Trajectories in Established Bronchopulmonary Dysplasia: The LIBERATE-BPD StudyK23HL175207 · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · 2025 to 2025
$179k
NHLBI NIH HHS K23 HL175207NHLBI NIH HHS T32 HL160493NIEHS NIH HHS P30 ES013508
6 · The paper itself

Abstract

Bronchopulmonary dysplasia (BPD) remains a prevalent and complex complication of preterm birth, yet current definitions fail to capture the heterogeneous and evolving nature of the disease. Longitudinal studies reveal persistent pulmonary disease throughout the lifespan. Despite progress in identifying phenotypes, biomarkers to characterize disease endotypes to guide effective and precise therapies remain elusive. Precision medicine approaches, including multicenter deep phenotyping and integration of multi-omic data, are essential to identify meaningful disease subtypes that inform individualized care. This perspective traces the evolution of BPD definitions, outlines their limitations, and presents a path forward focused on collaborative data networks, enriched trial designs, and longitudinal outcome measures. Recognizing BPD and subsequent cardiopulmonary disease related to prematurity as a lifelong disease, not just a NICU outcome, is critical to improving long-term care and developing targeted interventions for this vulnerable population.

Indexed as

Bronchopulmonary DysplasiaPrecision MedicineBiomarkersHumansInfant, NewbornInfant, PrematurePhenotypeBiomarkers

Identifiers

PMID41490933
PMCPMC12910485

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.