Evidence map›Paper›PMID 41490941›Full record

SynthesisScientific reports2026

Lean tissue mass is associated with adverse outcomes across different stages of chronic kidney disease: a systematic review and meta-analysis.

Matthew Tabinor, Emma Elphick, Charlotte Stephens, Nadya Wall, Azm Ul Hussain, Rafeea Shah, Michael Sagmeister, Anna M Price, Javeria Peracha, Benjamin Anderson and 6 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Matthew TabinorDepartment of Renal Medicine, Royal Stoke University Hospital, University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK. m.tabinor@keele.ac.uk.
Emma ElphickDepartment of Renal Medicine, University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, UK.
Charlotte StephensDepartment of Renal Medicine, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Trust, Birmingham, UK.
Nadya WallDepartment of Renal Medicine, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK.
Azm Ul HussainDepartment of Renal Medicine, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Trust, Birmingham, UK.
Rafeea ShahDepartment of Renal Medicine, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Trust, Birmingham, UK.
Michael SagmeisterDepartment of Renal Medicine, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Trust, Birmingham, UK.
Anna M PriceDepartment of Renal Medicine, Birmingham Heartlands Hospital, University Hospitals Birmingham NHS Trust, Birmingham, UK.
Javeria PerachaDepartment of Renal Medicine, Birmingham Heartlands Hospital, University Hospitals Birmingham NHS Trust, Birmingham, UK.
Benjamin AndersonDepartment of Renal Medicine, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Trust, Birmingham, UK.
Obaida IstanbulySchool of Medicine, Keele University, Newcastle-under-Lyme, UK.
James H SavageDepartment of Renal Medicine, Dudley Group NHS Trust, Dudley, UK.
John BelcherSchool of Medicine, Keele University, Newcastle-under-Lyme, UK.
Ivonne Solis-TrapalaSchool of Medicine, Keele University, Newcastle-under-Lyme, UK.
Charles J FerroDepartment of Renal Medicine, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Trust, Birmingham, UK.
Simon J DaviesSchool of Medicine, Keele University, Newcastle-under-Lyme, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In chronic kidney disease it is hypothesised that the association between loss of lean tissue mass (LLTM) and mortality is purely a function of multimorbidity. We conducted a systematic review in CKD patients to quantify the strength of association between LLTM and mortality or frailty surrogates, including hospitalisation and quality of life (QoL). Muscle mass was estimated using different whole-body bioimpedance methods (BI-MM). Searches of electronic databases identified 132 studies for inclusion (147542 dialysis patients; 15378 CKDG3−5 patients; 356 kidney transplant recipients [KTR], with 14429 deaths). From 67 studies reporting unadjusted analyses, 52 (78%) demonstrated associations between LLTM and mortality. In 80 studies reporting analyses adjusting for age, sex, and multimorbidity, 59 (74% overall: 74, 67 and 100% in dialysis, CKD, and KTR studies respectively) reported an association. Meta-analysis of dialysis studies reporting adjusted survival analyses found each degree decrease in phase angle or a lean tissue index < 10th percentile was associated with a 92 and 49% higher hazard of mortality respectively. In studies reporting hospitalisation and QoL measures, 63 and 76% reported associations with BI-MM respectively. In conclusion, having accounted for multimorbidity, LLTM remained associated with mortality and frailty surrogates in CKD, irrespective of the BI-MM method used.

Indexed as

Body CompositionRenal Insufficiency, ChronicFemaleHospitalizationHumansKidney TransplantationQuality of LifeRenal DialysisBioimpedanceBody compositionChronic kidney diseaseDialysisKidney transplantLean tissue mass

Identifiers

PMID41490941
PMCPMC12855913

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.