ArticleBiological trace element research2026
Elemental and Isotopic Profiles in Blood and Urine of Jordanian Children with Autism Spectrum Disorder: a Preliminary Comparative Study with Neurotypical Children.
Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that may involve disruptions in metal homeostasis. This study explores the novel use of stable isotope ratios as biomarkers for ASD. The isotopic compositions of essential elements (Mg, Cr, Fe, Cu, Zn, Sr) were measured in blood and urine of children with ASD and neurotypical children to predict condition severity. 38 children (20 with ASD, 18 neurotypical), aged 2–6 years were recruited. Inductively coupled plasma mass spectrometry (ICP-MS) was used to analyze elemental and isotopic concentrations. Results revealed children with ASD had substantially lower blood levels of chromium (e.g., ⁵²Cr: 7.14 × 10¹±5.93 vs. neurotypical, p = 0.004) and copper (e.g., ⁶⁵Cu: 4.63 × 10¹±5.33, p = 0.004), with large effect sizes (Cohen’s d> -0.98). These findings remained significant after false discovery rate correction. Notably, distinct isotopic fractionation was observed. The ASD group showed pronounced enrichment of heavy magnesium (²⁶Mg) in blood, with a δ-value of 6604.14 compared to 5444.84 in neurotypical. Conversely, a significant depletion of heavy zinc (⁶⁶Zn) was found in ASD blood (δ-value: 1113.45 vs. 1619.64 in neurotypical). In urine, magnesium isotopes were significantly reduced (e.g., ²⁴Mg: 3.23 × 10³±1.34 × 10³ in ASD vs. neurotypical, p = 0.001). Predictive modeling using δ-values differentiated between both groups. The isotopic ratios, particularly δ²⁶Mg/²⁴Mg in blood and δ²⁵Mg/²⁴Mg in urine, were more discriminative than absolute concentrations, highlighting their potential as sensitive biomarkers of altered metal metabolism in ASD. This study concludes that stable isotope analysis of blood and urine presents a promising tool for developing biomarkers to aid severity prediction of ASD.
Indexed as
Identifiers
41491150What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.