Evidence map›Paper›PMID 41491271›Full record

ArticleInternational journal of obesity (2005)2026

The effect of obesity and aging on NAD

Helena A K Lapatto, Birgitta W van der Kolk, Maheswary Muniandy, Sini Heinonen, Aino Heikkinen, Marcus Alvarez, Seung Hyuk T Lee, Riikka Jokinen, Jesper Lundbom, Juho Kuula and 8 more

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Helena A K LapattoObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland. helena.lapatto@helsinki.fi.ORCID 0000-0002-6655-4415
Birgitta W van der KolkObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0001-8608-541X
Maheswary MuniandyObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0001-7624-7948
Sini HeinonenObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-6342-0577
Aino HeikkinenInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0001-5770-6475
Marcus AlvarezDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Seung Hyuk T LeeDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID 0000-0002-0943-6076
Riikka JokinenObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Jesper LundbomDepartment of Radiology, Medical Imaging Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Juho KuulaDepartment of Radiology, Medical Imaging Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Antti HakkarainenDepartment of Radiology, Medical Imaging Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Per-Henrik GroopFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Jaakko KaprioInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-3716-2455
Taru TukiainenInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Miina OllikainenInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-3661-7400
Päivi PajukantaDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Eija PirinenResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Kirsi H PietiläinenObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland. kirsi.pietilainen@helsinki.fi.ORCID 0000-0002-8522-1288

Funding

Training Grant in Genomic Analysis and InterpretationT32HG002536 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Valerie A Arboleda, Harold Pimentel · 2002 to 2026
$8.6M
NHGRI NIH HHS T32 HG002536
6 · The paper itself

Abstract

introductionThe expression and/or activity of sirtuins (SIRTs), nicotinamide adenine dinucleotide (NAD

methodsWe examined 49 monozygotic twin pairs discordant for BMI (within-pair difference in BMI ≥ 2.5 kg/m

resultsSIRT5 and NAD

conclusionImpaired NAD

Indexed as

AgingDNA MethylationNADObesitySirtuinsSubcutaneous FatAdultAgedBody Mass IndexFemaleHumansMaleMiddle AgedTwins, MonozygoticYoung AdultNADSirtuins

Identifiers

PMID41491271
PMCPMC13056538

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.