Evidence map›Paper›PMID 41491303›Full record

ArticleNature metabolism2026

Hepatic GPR110 contributes to sex disparity in the development of MASH through oestrogen receptor α-dependent signalling.

Fang Yang, Wei Wang, Feng Qiu, Rui Qing, Qingying Gao, Xingqun Yan, Donghai Wu, Hannah Xiaoyan Hui, Rui Dang, Guozhi Jiang and 14 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Fang Yang *School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Wei Wang *Department of Endocrinology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Feng QiuSchool of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Rui QingSchool of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.ORCID http://orcid.org/0000-0002-7952-2295
Qingying GaoSchool of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Xingqun YanSchool of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Donghai WuGuangzhou Institute of Biomedical Health, Chinese Academy of Sciences, Guangzhou, China.
Hannah Xiaoyan HuiSchool of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.ORCID http://orcid.org/0000-0002-7525-5812
Rui DangSchool of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, China.
Guozhi JiangSchool of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, China.
Liyuan HanDepartment of Clinical Epidemiology, Ningbo, China.
Chunhao LongSchool of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Shuang HuaDepartment of Cardiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Yixuan ZhangSchool of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Siwei JiSchool of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Lu XuSchool of Life Sciences, Westlake University, Hangzhou, China.
Chen ZhouDepartment of Ultrasound, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Daiqiang XuDepartment of Endocrinology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Alessandro CherubiniPrecision Medicine-Biological Resource Center and Department of Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Luca ValentiPrecision Medicine-Biological Resource Center and Department of Transfusion Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Ping GuDepartment of Endocrinology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. guping@nju.edu.cn.ORCID http://orcid.org/0000-0002-7091-871X
Shufei ZangDepartment of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China. sophiazsf@fudan.edu.cn.ORCID http://orcid.org/0009-0005-9812-7679
Weimin JiangDepartment of Cardiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. jwm0410@njucm.edu.cn.ORCID http://orcid.org/0000-0002-9681-8960
Zhe HuangSchool of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China. zhehuang@sjtu.edu.cn.ORCID http://orcid.org/0000-0003-4943-3723

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82100906National Natural Science Foundation of China (National Science Foundation of China) 82370865Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) 22ZR1430400
6 · The paper itself

Abstract

Metabolic dysfunction-associated steatohepatitis (MASH) is an important phase in the progression of metabolic dysfunction-associated steatotic liver disease to end-stage liver diseases, posing an increasing threat to public health worldwide with limited treatment options. Here we show that GPR110 is a liver-selective G-protein-coupled receptor closely associated with MASH in a sex-specific manner. Hepatocyte-specific Gpr110 knockout protects against MASH in female, but not male mice. The GPR110 variant rs937057 T > C is associated with a higher prevalence of metabolic dysfunction-associated steatotic liver disease in women. The improved liver phenotypes in female mice are abrogated by knocking down the expression of hepatic oestrogen receptor alpha (Esr1). Mechanistically, GPR110 couples to Gα

Indexed as

Estrogen Receptor alphaFatty LiverLiverReceptors, G-Protein-CoupledAnimalsFemaleHepatocytesHumansMaleMiceMice, Inbred C57BLMice, KnockoutSex CharacteristicsSex FactorsSignal TransductionEsr1 protein, mouseEstrogen Receptor alphaReceptors, G-Protein-Coupled

Identifiers

PMID41491303

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.