ArticleEuropean journal of medical research2026
Mitochondrial-related biomarkers as the diagnostic markers in sepsis induced acute respiratory distress syndrome.
Article in European journal of medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Identification of immune cell mitochondrial dysfunction characteristics and clinical predictive biomarkers in sepsis via multi-cohort machine learning and single-cell RNA sequencing.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
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Authors and funding
6 authors.
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Abstract
Previous study found that mitochondrial might correlate with sepsis-induced acute respiratory distress syndrome (ARDS). Thus, this study aimed to find the effect of mitochondrial-related biomarkers in sepsis-induced ARDS. Differentially expressed genes (DEGs) were firstly screened in sepsis-induced ARDS datasets and intersected with mitochondrial-related genes (MRGs) to create differentially expressed-MRGs (DE-MRGs). Based on DE-MRGs, three machine learning algorithms were further performed to yield feature genes, the intersections of feature genes were conducted expression analysis. Those genes with significant difference of expression were identified as biomarkers for nomogram construction and immune infiltration. Single cell RNA sequencing (scRNA-seq) analysis was processed to annotate cell subpopulations, the expression of biomarkers was evaluated in different cell subpopulations. Finally, the expression of biomarkers was validated by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blotting. Relied on comprehensive analysis, three biomarkers (ARID4B, RGS2, TGM2) related to mitochondrial were acquired for sepsis-induced ARDS. A nomogram was then constructed relied on biomarkers, and verified to have an excellent performance. Analysis of immune infiltration showed that naive B cells and CD8
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