SynthesisBMC geriatrics2026
Deprescribing antihypertensive medications in older people: a systematic review and a meta-analysis.
Synthesis in BMC geriatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Season-adaptive blood pressure management in older adults with CKD: a practical review.Clinical and experimental nephrology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
introductionHypertension is highly prevalent among older people, and the balance of benefit and harm of antihypertensive therapy may shift with age. In certain cases, reducing or discontinuing antihypertensive treatment (deprescribing) may be appropriate. This systematic review and meta-analysis aimed to summarize available evidence on deprescribing antihypertensive medications in older adults aged 65 years and older.
methodsWe searched MEDLINE, Embase, CINAHL, the Cochrane Library, the Web of Science Core Collection, ClinicalTrials.gov, ICTRP and Epistemonikos from inception to July 2024. We included randomized controlled trials (RCTs) and comparative observational studies (OS) comparing deprescribing versus continuation of antihypertensive medications in adults ≥ 65 years. The primary outcome was all-cause mortality. Secondary outcomes included myocardial infarction, heart failure, stroke, major adverse cardiovascular events (MACE), orthostatic hypotension and falls. Where possible, data were synthesized using meta-analysis to estimate odds ratios (ORs) and 95% Confidence Intervals (CI). We assessed the risk of bias in the RCTs in Covidence basing on the Cochrane Risk Of Bias (Rob 2) tool. For the observational studies we used the Newcastle Ottawa Scale for comparative observational studies.
resultsWe included 17 studies. Results from the observational studies are only reported as narrative summary. The pooled OR for all-cause mortality was 1.11 (95% CI 0.82-1.50; 6 RCTs). For secondary outcomes, pooled ORs were 1.32 (95% CI 0.30-5.92) for myocardial infarction (3 RCTs), 3.16 (95% CI 1.53-6.55) for heart failure (3 RCTs), and 3.08 (95% CI 0.73-13.00) for stroke (4 RCTs).
conclusionThe effects of deprescribing antihypertensive medications in older adults remain uncertain. The limited and low-event-rate evidence on key cardiovascular outcomes for older individuals highlights the need for individualized decision-making, especially in frail and multimorbid populations. This review provides a foundation for future research to address gaps and guide safer deprescribing practices in older adults in routine clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.