Neural Gastric Electrical Stimulation: Future Prospects in Managing Gastric Emptying Disorders.

Jonathan Sivakumar, John B Furness, David B Grayden, James Fallon, Jeremy Cottrell, Cuong Phu Duong

Abstract readReview

In one paragraph

Review in Journal of neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jonathan SivakumarDepartment of Upper Gastrointestinal Surgery, Peter MacCallum Cancer Center, Melbourne, Australia.

John B FurnessDepartment of Anatomy and Physiology and Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.

David B GraydenDepartment of Biomedical Engineering and Graeme Clark Institute, The University of Melbourne, Parkville, Australia.

James FallonBionics Institute, Fitzroy, Australia.

Jeremy CottrellFaculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Australia.

Cuong Phu DuongDepartment of Upper Gastrointestinal Surgery, Peter MacCallum Cancer Center, Melbourne, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neural gastric electrical stimulation (NGES) is a multi-channel high-energy gastrointestinal stimulation technique that directly activates cholinergic motor neurons to evoke contractions that improve gastric emptying. NGES stimulation superimposes on spontaneous electromechanical activity to generate coordinated propagating contractions. In contrast, the most commonly applied form of gastric electrical stimulation (Enterra), employs paired pulses that stimulate vagal afferent pathways to reduce symptoms of nausea and vomiting, but does not enhance emptying. This review examines the evolution and implementation of NGES, focusing on its potential role as a treatment option to enhance gastric propulsion in gastroparesis and delayed gastric conduit emptying. While initial acute animal studies have shown promising results, continued development of the technology and refinement of stimulation protocols through chronic experiments remains essential for successful clinical translation.

Indexed as

Delayed gastric conduit emptyingElectric stimulation therapyGastrointestinal motilityStomach physiology

Identifiers

PMID41492155

DOI10.5056/jnm25106

PMCPMC12780909

What Socratic holds

Textmetadata

LicenceCC BY-NC

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.