Evidence map›Paper›PMID 41492425›Full record

ArticlePreventive nutrition and food science2025

Effect of Dietary Sodium Nitrite Supplementation on Spontaneous Intracerebral Hemorrhage in Stroke-Prone Spontaneously Hypertensive Rats.

Shang Ran, Yuka Kono, Kunihiro Sonoda, Kazuya Kitamori, Kazuo Ohtake, Mari Mori, Theodore W Kurtz, Yukio Yamori, Jun Kobayashi, Hinako Nakayama and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Preventive nutrition and food science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Shang RanDepartment of Medical Laboratory Science, Graduate School of Health Sciences, Okayama University, Okayama 700-8558, Japan.ORCID https://orcid.org/0009-0002-7484-7872
Yuka KonoDepartment of Medical Laboratory Science, Graduate School of Health Sciences, Okayama University, Okayama 700-8558, Japan.ORCID https://orcid.org/0009-0000-0540-9989
Kunihiro SonodaDepartment of Food and Nutritional Environment, College of Human Life and Environment, Kinjo Gakuin University, Aichi 463-8521, Japan.ORCID https://orcid.org/0009-0006-3390-0816
Kazuya KitamoriDepartment of Food and Nutritional Environment, College of Human Life and Environment, Kinjo Gakuin University, Aichi 463-8521, Japan.ORCID https://orcid.org/0009-0000-9961-4894
Kazuo OhtakeDivision of Physiology, School of Pharmaceutical Sciences, Faculty of Pharmaceutical Science, Josai University, Saitama 350-0295, Japan.ORCID https://orcid.org/0009-0000-7137-928X
Mari MoriDepartment of Health Management, School of Health Studies, Tokai University, Kanagawa 259-1292, Japan.ORCID https://orcid.org/0009-0003-7196-4114
Theodore W KurtzDepartment of Laboratory Medicine, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID https://orcid.org/0000-0003-0436-5456
Yukio YamoriResearch Institute for Health Science, Mukogawa Women's University, Hyogo 662-0833, Japan.ORCID https://orcid.org/0009-0007-2274-2514
Jun KobayashiDivision of Pathophysiology, Department of Clinical Dietetics and Human Nutrition, Josai University, Saitama 350-0295, Japan.ORCID https://orcid.org/0000-0002-3490-2980
Hinako NakayamaDepartment of Medical Laboratory Science, Graduate School of Health Sciences, Okayama University, Okayama 700-8558, Japan.ORCID https://orcid.org/0009-0009-1210-6068
Taketo FukuokaDepartment of Medical Laboratory Science, Graduate School of Health Sciences, Okayama University, Okayama 700-8558, Japan.ORCID https://orcid.org/0009-0005-2669-0331
Yuki KawaiDepartment of Medical Laboratory Science, Graduate School of Health Sciences, Okayama University, Okayama 700-8558, Japan.ORCID https://orcid.org/0009-0005-1496-6097
Haruka TagoDepartment of Medical Laboratory Science, Graduate School of Health Sciences, Okayama University, Okayama 700-8558, Japan.ORCID https://orcid.org/0009-0006-6241-4665
Nobuhisa WatanabeDepartment of Medical Laboratory Science, Graduate School of Health Sciences, Okayama University, Okayama 700-8558, Japan.ORCID https://orcid.org/0009-0002-0539-5104
Ikumi SatoDepartment of Medical Laboratory Science, Faculty of Health Sciences, Okayama University, Okayama 700-8558, Japan.ORCID https://orcid.org/0009-0003-4923-6532
Shusei YamamotoDepartment of Medical Laboratory Science, Faculty of Health Sciences, Okayama University, Okayama 700-8558, Japan.ORCID https://orcid.org/0009-0004-0582-2879
Satoshi HirohataDepartment of Medical Laboratory Science, Faculty of Health Sciences, Okayama University, Okayama 700-8558, Japan.ORCID https://orcid.org/0000-0002-4815-5891
Shogo WatanabeDepartment of Medical Laboratory Science, Faculty of Health Sciences, Okayama University, Okayama 700-8558, Japan.ORCID https://orcid.org/0000-0002-1700-2892

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diet-derived nitrite can benefit cardiovascular function. However, the effects of nitrite supplementation on idiopathic intracerebral hemorrhage (spontaneous ICH) are unclear. This study, therefore, investigated the impacts of chronic nitrite supplementation on the survival rate and risk for spontaneous ICH in stroke-prone spontaneously hypertensive/Izumo strain (SHRSP/Izm) rats fed with a high-salt diet. Experimental study I-six-week-old male rats were categorized into two groups: (1) SHRSP+salt, in which rats were administered saline drinking water, and (2) SHRSP+salt+nitrite, in which rats were administered nitrite-added saline drinking water for 14 weeks each. The survival curves during this period did not vary significantly between the groups. However, nitrite administration markedly reduced the incidence of ICH and the extent of cerebral hemorrhage. Experimental study II-the impacts of nitrite supplementation on blood pressure in salt-loaded 8-week-old male SHRSP/Izm rats were evaluated for >4 weeks. During the first week, systolic blood pressure was remarkably lower in the nitrite group than in the control (without nitrite feeding). Similarly, at week 4, cardiac mass and brain mass were significantly lower. In conclusion, nitrite treatment reduced the extent of cerebral hemorrhage caused by hypertension and administration of a high-salt diet.

Indexed as

cerebral hemorrhagehypertensionnitric oxidenitrites

Identifiers

PMID41492425
PMCPMC12765616

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.