Evidence map›Paper›PMID 41492649›Full record

ReviewMaterials today. Bio2026

Combating posterior capsular opacification: From conventional intraocular lens modifications to proactive defense via interface engineering.

Xueshan Zhao, Panpan Deng, Jingyu Zou, Xiaohe Xu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xueshan ZhaoDepartment of Ophthalmology, Shengjing Hospital of China Medical University, No. 36 Nansanhao Street, Shenyang, 110004, China.
Panpan DengDepartment of Ophthalmology, Shengjing Hospital of China Medical University, No. 36 Nansanhao Street, Shenyang, 110004, China.
Jingyu ZouDepartment of Neurosurgery, First Affiliated Hospital, China Medical University, Shenyang, 110001, China.
Xiaohe XuDepartment of Ophthalmology, Shengjing Hospital of China Medical University, No. 36 Nansanhao Street, Shenyang, 110004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Posterior capsular opacification (PCO), the most common complication after intraocular lens (IOL) implantation, can be mitigated but is not fully prevented using conventional IOL strategies. These strategies include material optimization (e.g., hydrophobic acrylate), mechanical barrier design (e.g., sharp edges), and biological modifications (e.g., heparin surface-modified IOLs). In this review, we discuss the pathological mechanisms of PCO, briefly trace the evolution of traditional functional IOLs, and critically analyze their limitations in terms of passive defense. We then systematically elaborate on proactive interface engineering-driven strategies, including drug-delivering IOLs, biofunctionalized IOLs, and stimuli-responsive IOLs, that precisely regulate lens epithelial cell (LEC) activity and microenvironment remodeling through surface functionalization. Challenges in efficacy evaluation and clinical translation, such as key

Indexed as

Biofunctionalized IOLFunctional IOLInterface engineeringIntraocular lensPosterior capsular opacificationResponsive IOL

Identifiers

PMID41492649
PMCPMC12765344

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.