ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
[Correlation between the systemic immune
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesCarotid atherosclerosis (CAS) plaques are independent risk factors for stroke, and chronic vascular inflammation is involved in their pathogenesis. This study aims to explore the association between the systemic immune-inflammation index (SII) and CAS, analyze sex-specific differences in this association, and provide evidence for the early prevention and control of atherosclerosis.
methodsThis single-center cross-sectional study included adults who underwent health examinations and completed carotid ultrasound assessments at Xiangya Hospital of Central South University between January and December 2023, among whom those with CAS were classified as a CAS group, and those without CAS were classified as a normal control group. Demographic characteristics, anthropometric measurements, and laboratory data were collected. Participants were categorized into Quartile 1 to 4 based on SII . Four binary logistic regression models were constructed to progressively adjust for confounders and evaluate the association between SII and CAS, with further stratification by sex. Mediation analyses stratified by sex. Mediation analyses stratified by sex were performed using the Bootstrap method (5 000 resamplings), with white blood cell and monocyte counts as mediators. Sensitivity analyses were conducted to verify robustness.
resultsA total of 19 788 participants were included, of whom 7 567 (38.24%) had CAS. Compared with controls, individuals with CAS had significantly higher proportions of males, age, waist circumference, systolic and diastolic blood pressure, fasting glucose, and white blood cell count (all
conclusionsA significant sex-specific heterogeneity exists in the association between SII and CAS. High SII is an independent correlate of CAS in women, driven primarily by direct effects and not mediated by white blood cell or monocyte counts. In men, SII influences CAS predominantly through complete mediation by white blood cells and partial mediation by monocytes. These findings suggest the differentiated value of SII in CAS risk assessment across sexes and provide evidence to support sex-targeted screening and intervention strategies.
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