Evidence map›Paper›PMID 41492840›Full record

ArticleJournal of cellular and molecular medicine2026

Aesculus hippocastanum Extract Exerts Neuroprotective Effects in an MPP

Sarah Adriana Scuderi, Alessio Ardizzone, Giovanna Casili, Deborah Mannino, Antonio Catalfamo, Marika Lanza, Emanuela Esposito

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah Adriana ScuderiGenetics and Pharmacogenetics Unit, 'Gaetano Martino' University Hospital, Messina, Italy.ORCID https://orcid.org/0000-0001-8566-9739
Alessio ArdizzoneUniCamillus-Saint Camillus International University of Health Sciences, Rome, Italy.
Giovanna CasiliDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Deborah ManninoResearch Operative Unit of Neuropharmacology and Translational Neurosciences, Oasi Research Institute, IRCCS, Troina, Italy.
Antonio CatalfamoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Marika LanzaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.ORCID https://orcid.org/0000-0002-0742-8005
Emanuela EspositoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.ORCID https://orcid.org/0000-0002-2663-6387

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the loss of dopaminergic neurons in the substantia nigra. In this study, we investigated the neuroprotective and anti-inflammatory potential of Aesculus hippocastanum (horse chestnut extract, HCE) in an in vitro model of PD. Human neuroblastoma SH-SY5Y cells were treated with the neurotoxin 1-methyl-4-phenylpyridinium (MPP

Indexed as

AesculusNeuroprotective AgentsParkinson DiseasePlant ExtractsPPAR gamma1-Methyl-4-phenylpyridiniumCell Line, TumorCell SurvivalCytokinesDopaminergic NeuronsHumansNF-kappa BOxidative StressSignal Transduction1-Methyl-4-phenylpyridiniumCytokinesNeuroprotective AgentsNF-kappa BPlant ExtractsPPAR gammaAesculus hippocastanumneuroinflammationoxidative stressParkinson's disease (PD)peroxisome proliferator activated receptor gamma (PPARγ)

Identifiers

PMID41492840
PMCPMC12771594

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.