Evidence map›Paper›PMID 41493395›Full record

ArticlePlant biotechnology journal2026

H3K27me3-Mediated Epigenetic Silencing of FgHMG1 Enables Fungal Host Immune Evasion.

Xiaozhen Zhao, Bingqin Yuan, Peixue Ma, Yajie Cai, Yan Huang, Yaxuan Wang, Zhen Cheng, Yuan Chen, Minghong Zheng, Ran Zhang and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Xiaozhen ZhaoAnhui Province Key Laboratory of Integrated Pest Management on Crops, School of Plant Protection, Anhui Agricultural University, Hefei, China.
Bingqin YuanState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Peixue MaAnhui Province Key Laboratory of Integrated Pest Management on Crops, School of Plant Protection, Anhui Agricultural University, Hefei, China.
Yajie CaiAnhui Province Key Laboratory of Integrated Pest Management on Crops, School of Plant Protection, Anhui Agricultural University, Hefei, China.
Yan HuangAnhui Province Key Laboratory of Integrated Pest Management on Crops, School of Plant Protection, Anhui Agricultural University, Hefei, China.
Yaxuan WangAnhui Province Key Laboratory of Integrated Pest Management on Crops, School of Plant Protection, Anhui Agricultural University, Hefei, China.
Zhen ChengAnhui Province Key Laboratory of Integrated Pest Management on Crops, School of Plant Protection, Anhui Agricultural University, Hefei, China.
Yuan ChenState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Minghong ZhengState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Ran ZhangState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Jinmei WuState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Xieyu LiState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Mohan WangState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Huijun WuState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.ORCID https://orcid.org/0000-0001-5586-1607
Chengqi ZhangAnhui Province Key Laboratory of Integrated Pest Management on Crops, School of Plant Protection, Anhui Agricultural University, Hefei, China.
Xuewen GaoState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.
Li ChenAnhui Province Key Laboratory of Integrated Pest Management on Crops, School of Plant Protection, Anhui Agricultural University, Hefei, China.
Qin GuState Key Laboratory of Agricultural and Forestry Biosecurity, College of Plant Protection, Nanjing Agricultural University, Nanjing, China.

Funding

Fundamental Research Funds for the Central Universities KJJQ2025025Joint Research Program of State Key Laboratory of Agricultural and Forestry Biosecurity SKLJRP2510National Key R&D Program of China 2022YFD1400102National Key R&D Program of China 2024YFD1401103National Natural Science Foundation of China 32402305National Natural Science Foundation of China 32472535Natural Science Foundation for Distinguished Young Scholars of Jiangsu Province BK20240088Science and Technology Planning Project of Jurong City ZA32320Talent Research Project of Anhui Agricultural University rc342502
6 · The paper itself

Abstract

Histone H3 lysine 27 trimethylation (H3K27me3) is essential for fungal pathogenicity, yet its contribution to pathogen-host interactions remains incompletely understood. Here, we profiled H3K27me3 dynamics in Fusarium graminearum during infection and identified 132 H3K27me3-marked genes (FgHMGs). Among these, FgHMG1 encodes a secreted glycoside hydrolase family 11 (GH11) protein that functions as a pathogen-associated molecular pattern (PAMP), triggering PAMP-triggered immunity (PTI) in Nicotiana benthamiana through the receptor kinases BAK1 and SOBIR1, independently of its enzymatic activity. FgHMG1 also induces reactive oxygen species (ROS) accumulation and upregulation of defence-related genes in wheat plants. Remarkably, FgHMG1 expression is repressed during host invasion by the histone methyltransferase FgKMT6, a homologue of Enhancer of zeste (E(z)) from Drosophila, via H3K27me3 deposition, enabling immune evasion. Loss of FgKMT6 abolishes H3K27me3 enrichment, derepresses FgHMG1, and enhances host immunity, effects largely rescued in ΔFgKMT6-FgHMG1 double mutants. Notably, foliar application of recombinant FgHMG1 protein reduced Fusarium head blight severity in wheat by 35%-50% in 2-year field trials. These findings reveal that fungal pathogens exploit H3K27me3-mediated silencing of immunogenic PAMP genes to evade host recognition and highlight FgHMG1 as a promising candidate for crop protection.

Indexed as

Epigenesis, GeneticFungal ProteinsFusariumHistonesImmune EvasionGene Expression Regulation, FungalGene SilencingHost-Pathogen InteractionsNicotianaPlant DiseasesPlant ImmunityReactive Oxygen SpeciesTriticumFungal ProteinsHistonesReactive Oxygen Speciesepigenetic regulationFusarium graminearumH3K27me3 modificationimmune evasionPAMPplant immunity

Identifiers

PMID41493395
PMCPMC13110184

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.