Evidence map›Paper›PMID 41494533›Full record

ArticleCell reports. Medicine2026

5-HT reuptake blockade induces pyroptosis in BRAF

Aicun Li, Shoujia Xu, Jiachen Fan, Jingwei Liu, Xiaoyu Song, Liu Cao, Zhicheng Gong, Xiao Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. The gasdermin family: from pyroptosis mechanisms to therapeutic targets.Signal transduction and targeted therapy · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Quinone reductase 2bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aicun LiThe College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
Shoujia XuDepartment of Cell Biology, Basic Medical College, Naval Medical University (Second Military Medical University), Shanghai, China.
Jiachen FanThe College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
Jingwei LiuThe College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
Xiaoyu SongThe College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, Liaoning, China.
Liu CaoThe College of Basic Medical Science, Health Sciences Institute, China Medical University, Shenyang, Liaoning, China. Electronic address: lcao@cmu.edu.cn.
Zhicheng GongWuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China. Electronic address: jichan@jiangnan.edu.cn.
Xiao LuDepartment of Cell Biology, Basic Medical College, Naval Medical University (Second Military Medical University), Shanghai, China. Electronic address: 592647819@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dual challenges of limited therapeutic options due to de novo or acquired resistance and psychological distress in patients with melanoma necessitate innovative treatment strategies. Here, we identify paroxetine hydrochloride (PH), a Food and Drug Administration (FDA)-approved antidepressant, as an alternative therapeutic for BRAF

Indexed as

HistonesMelanomaProto-Oncogene Proteins B-rafPyroptosisSelective Serotonin Reuptake InhibitorsSerotoninAnimalsCell Line, TumorHumansMiceMutationTumor MicroenvironmentBRAF protein, humanHistonesProto-Oncogene Proteins B-rafSelective Serotonin Reuptake InhibitorsSerotonin5-hydroxytryptamineBRAF mutationdrug repurposingdrug resistancegenomic instabilityhistone serotonylationimmunotherapymelanomaproteostasispyroptosis

Identifiers

PMID41494533
PMCPMC12866116

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.