Evidence map›Paper›PMID 41494651›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2026

Tumor necrosis factor α-induced endoplasmic reticulum stress promotes airway smooth muscle cell proliferation.

Debanjali Dasgupta, Gary C Sieck

Abstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Debanjali DasguptaDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0001-8307-9719
Gary C SieckDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0003-3040-9424

Funding

Impact of Airway Inflammation on MitochondriaR01HL157984 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S., SIECK, GARY C. · 2021 to 2024
$2.7M
HHS | National Institutes of Health (NIH) HL157984NHLBI NIH HHS R01 HL157984
6 · The paper itself

Abstract

Proinflammatory cytokines such as tumor necrosis factor alpha (TNFα) induce airway smooth muscle (ASM) cell proliferation. Previously, we showed that TNFα induces an endoplasmic reticulum (ER) stress response involving autophosphorylation of inositol requiring enzyme 1α at serine 724 (pIRE1α

Indexed as

Cell ProliferationEndoplasmic Reticulum StressMyocytes, Smooth MuscleTumor Necrosis Factor-alphaCells, CulturedCyclin B1EndoribonucleasesFemaleHumansMaleProtein Serine-Threonine KinasesX-Box Binding Protein 1Cyclin B1EndoribonucleasesERN1 protein, humanProtein Serine-Threonine KinasesTumor Necrosis Factor-alphaX-Box Binding Protein 1XBP1 protein, humanairway inflammationairway remodelingcell proliferationER stressTNFα

Identifiers

PMID41494651
PMCPMC12911424

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.