Evidence map›Paper›PMID 41495150›Full record

ArticleScientific reports2026

Lipocalin-2 upregulation in hypoxic murine osteocytes enhances RANKL-induced osteoclastogenesis.

Kohei Narita, Fumitoshi Ohori, Aseel Marahleh, Jinghan Ma, Jiayi Ren, Angyi Lin, Ziqiu Fan, Kou Murakami, Hideki Kitaura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kohei NaritaDivision of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.
Fumitoshi OhoriDivision of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.
Aseel MarahlehDivision of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.
Jinghan MaDivision of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.
Jiayi RenDivision of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.
Angyi LinDivision of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.
Ziqiu FanDivision of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.
Kou MurakamiDivision of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.
Hideki KitauraDivision of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan. hideki.kitaura.b4@tohoku.ac.jp.

Funding

JSPS KAKENHI JP21K10178JSPS KAKENHI JP22K17244JST SPRING JPMJSP2114
6 · The paper itself

Abstract

Osteocytes regulate bone remodeling by interacting with osteoblasts and osteoclasts. Hypoxia influences osteocyte function and has been linked to increased osteoclastogenesis in pathological conditions such as orthodontic tooth movement (OTM) and bone metabolic diseases; however, the molecular mechanisms underlying these effects remain unclear. This study aimed to identify hypoxia-responsive genes in osteocytes and investigate their effects on osteoclastogenesis. Transcriptome analysis of murine long bone osteocyte-Y4 (MLO-Y4) osteocytes cultured under hypoxia (2% O

Indexed as

Lipocalin-2OsteocytesOsteogenesisRANK LigandAnimalsCell HypoxiaCells, CulturedMAP Kinase Signaling SystemMiceOsteoclastsOsteoprotegerinUp-RegulationLcn2 protein, mouseLipocalin-2OsteoprotegerinRANK LigandTnfsf11 protein, mouseHypoxiaLipocalin-2Orthodontic tooth movementOsteoclastOsteoclastogenesisOsteocyte

Identifiers

PMID41495150
PMCPMC12864796

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.