ReviewThe EMBO journal2026
Epimutations: raw material for evolution?
Review in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetics is fundamental to cell differentiation as it enables cells with identical genomes to adopt distinct fates. Some epigenetic information can also be transmitted between generations, in a process known as transgenerational epigenetic inheritance. This means that potentially epigenetic differences between individuals could contribute to diversity and thus be acted upon by evolution. These epigenetic differences are termed epimutations by analogy to the well-characterized DNA sequence mutations that underpin the standard model of evolution. Here, we evaluate the properties of epimutation, discussing their rate, genome-wide distribution, stability, and effects. Focusing on epimutations in animals, particularly the nematode C. elegans, we explore how epimutations compare to DNA sequence mutations in their potential to influence the processes of drift and natural selection that characterize evolution.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.