Evidence map›Paper›PMID 41495495›Full record

SynthesisAnnals of surgical oncology2026

Perioperative Depressive Symptoms in Surgical Cancer Patients: a Systematic Review and Meta-analysis.

Ellen O'Callaghan, Kristina Andrade, Nicole Rivera, Dana Rowe, Maya Blasingame, Kendall Reitz, Tara Dalton, Kerri-Anne Crowell, James Herndon, Samantha Kaplan and 6 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ellen O'CallaghanDepartment of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Kristina AndradeMorehouse School of Medicine, Atlanta, GA, USA.
Nicole RiveraDepartment of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Dana RoweDepartment of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Maya BlasingameDepartment of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Kendall ReitzDepartment of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Tara DaltonDepartment of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Kerri-Anne CrowellBiostatistics Shared Resource, Duke Cancer Institute, Durham, NC, USA.
James HerndonBiostatistics Shared Resource, Duke Cancer Institute, Durham, NC, USA.
Samantha KaplanMedical Center Library and Archives, Duke University, Durham, NC, USA.
Katherine L ApplegateDepartment of Psychiatry, Behavioral Sciences Duke Health, Durham, NC, USA.
Maria E GarciaDivision of General Internal Medicine, Department of Medicine, University of California, San Francisco, CA, USA.
Rafael De la Garza RamosDepartment of Neurosurgery, Montefiore Einstein, New York, NY, USA.
John H ShinDepartment of Neurosurgery, Penn Medicine, Philadelphia, PA, USA.
Melissa EricksonDepartment of Orthopedic Surgery, Duke University Medical Center, Durham, NC, USA.
C Rory GoodwinDepartment of Neurosurgery, Duke University Medical Center, Durham, NC, USA. spineresearch@dm.duke.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with cancer requiring surgery are at increased risk for depressive symptoms. However, prevalence and severity during the perioperative period are poorly characterized. This study systematically reviewed the perioperative prevalence of clinically significant depression and depressive symptom severity in patients with cancer, as measured by self-reported tools. PATIENTS AND

methodsA systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using PubMed, EMBASE, and Scopus databases (searched to 15 December 2023). Clinical studies of patients with cancer undergoing surgery that measured depressive symptoms using a self-reported instrument were included. Study quality and bias were assessed using the Oxford Centre for Evidence-Based Medicine Levels of Evidence and Joanna Briggs Institute Critical Appraisal Checklist. Data extracted included study characteristics, as well as prevalence and severity of depression pre- and postoperatively.

resultsData from 526 studies involving 103,075 surgical patients were included. The most common cancers were breast (32%), colorectal (10%), and head and neck (8%). The most frequently used tools were the Hamilton Anxiety and Depression Scale Depression Subscale (HADS-D, 52%), Beck's Depression Inventory (BDI, 10%), and the Center for Epidemiological Studies Depression Scale (10%). On average, 24% of patients reported clinically significant depressive symptoms, with higher prevalence preoperatively (P < 0.0001). This perioperative difference shifted to higher prevalence postoperatively for patients with other solid tumors when compared with those with breast or prostate cancer.

conclusionsA fourth of surgical cancer patients report clinically significant depressive symptoms in their perioperative course, with the preoperative timepoint presenting the greatest risk, extending to the immediately postoperative timepoint. This can inform mental health screening timing while considering cancer type.

Indexed as

DepressionNeoplasmsPerioperative PeriodHumansPrevalenceDepressionMental healthMeta-analysisPatients with cancerPerioperativeSurgerySystematic review

Identifiers

PMID41495495

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.