Evidence map›Paper›PMID 41495573›Full record

ArticleOdontology2026

IRF1-activated CA9 accelerates oral squamous cell carcinoma process via regulating cell glycolysis, migration, apoptosis and ferroptosis.

Yanrong Li, Yanhui Li, Shiying Liu

Abstract read
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In one paragraph

Article in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yanrong LiDepartment of Stomatology, Tianjin Third Central Hospital, No. 83 Jintang Road, Hedong District 300170, Tianjin, China.
Yanhui LiDepartment of Stomatology, Tianjin Third Central Hospital, No. 83 Jintang Road, Hedong District 300170, Tianjin, China.
Shiying LiuDepartment of Stomatology, Tianjin Third Central Hospital, No. 83 Jintang Road, Hedong District 300170, Tianjin, China. szxlsy2013@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbonic anhydrase 9 (CA9) is confirmed to be widely expressed in many malignant tumors, including oral squamous cell carcinoma (OSCC). However, more roles and potential molecular mechanisms of CA9 in OSCC progression need to be further elucidated. The mRNA and protein levels of CA9 and interferon regulatory factor-1 (IRF1) were determined by qRT-PCR and western blot. Cell glycolysis was assessed via detecting glucose uptake, lactate production, pH and oxygen consumption rate. Cell migration and apoptosis were measured using transwell assay and flow cytometry. Meanwhile, ROS, SOD, MDA and Fe

Indexed as

ApoptosisCarbonic Anhydrase IXCarcinoma, Squamous CellFerroptosisGlycolysisInterferon Regulatory Factor-1Mouth NeoplasmsAnimalsAntigens, NeoplasmCell Line, TumorCell MovementGene Expression Regulation, NeoplasticHumansMiceAntigens, NeoplasmCA9 protein, humanCarbonic Anhydrase IXInterferon Regulatory Factor-1IRF1 protein, humanCA9FerroptosisGlycolysisIRF1Oral squamous cell carcinoma

Identifiers

PMID41495573

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.