Evidence map›Paper›PMID 41495657›Full record

ArticleBMC genomics2026

PET microplastics induce lipotoxicity in the porcine pancreas.

Karol Mierzejewski, Aleksandra Kurzyńska, Monika Golubska, Robert Stryiński, Ismena Gałęcka, Jarosław Całka, Paula Borrajo, Manuel Pazos, Mónica Carrera, Iwona Bogacka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Karol MierzejewskiDepartment of Animal Anatomy and Physiology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1a, Olsztyn, 10-719, Poland. karol.mierzejewski@uwm.edu.pl.ORCID http://orcid.org/0000-0001-8976-7862
Aleksandra KurzyńskaDepartment of Animal Anatomy and Physiology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1a, Olsztyn, 10-719, Poland.
Monika GolubskaDepartment of Animal Anatomy and Physiology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1a, Olsztyn, 10-719, Poland.
Robert StryińskiDepartment of Biochemistry, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Ismena GałęckaDepartment of Epizootiology, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Jarosław CałkaDepartment of Clinical Physiology, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Paula BorrajoDepartment of Food Technology, Institute of Marine Research (IIM), Spanish National Research Council (CSIC), Vigo, Spain.
Manuel PazosDepartment of Food Technology, Institute of Marine Research (IIM), Spanish National Research Council (CSIC), Vigo, Spain.
Mónica CarreraDepartment of Food Technology, Institute of Marine Research (IIM), Spanish National Research Council (CSIC), Vigo, Spain.
Iwona BogackaDepartment of Animal Anatomy and Physiology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 1a, Olsztyn, 10-719, Poland.

Funding

Fundacja na rzecz Nauki Polskiej START 51/2024Narodowe Centrum Nauki 2022/47/B/NZ7/03026
6 · The paper itself

Abstract

Microplastics are a relatively new discovered environmental hazard that can contribute to the disruption of many physiological processes in the organism. There is evidence that they affect the physiology of the pancreas, but research in this area remains limited. Therefore, the aim of the study was to determine the effects of PET microplastics on the global proteomic profile of the pancreas using LC–MS/MS analysis, with the pig as a model organism. The pigs were treated either with a low (0.1 g/day) or a high dose (1 g/day) of PET microplastics for four weeks. The analysis revealed that PET microplastics affected protein abundance in a dose-dependent manner – the low dose altered the abundance of 7 proteins, while the high dose – 17. The differentially regulated proteins were involved in fatty acid biosynthesis (FASN, KAS), lipid peroxidation (CBR1) and digestive enzyme production (trypsinogen). Complementary colorimetric assays confirmed a significant increase in free fatty acids under the influence of a high dose of PET microplastics. Taken together, these results indicate that PET microplastics may affect oxidative status, induce lipotoxic stress and impair pancreatic exocrine function, suggesting a novel pathway through which microplastics may cause metabolic disturbances.

Indexed as

MicroplasticsPancreasAnimalsFatty AcidsLipid PeroxidationOxidative StressProteomeProteomicsSwineTandem Mass SpectrometryFatty AcidsMicroplasticsProteomeFatty acidPancreasPolyethylene terephthalateTrypsinogen

Identifiers

PMID41495657
PMCPMC12870336

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.