ReviewCell communication and signaling : CCS2026
The interplay between the extracellular matrix and extracellular vesicle-associated microRNAs.
Review in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Failure of morphogenesis in chronic inflammation-associated early tumourigenesis: Extracellular matrix biomechanics as an integrative layer.Biochemistry and biophysics reports · 2026Review
- Mechanisms of microRNA export in mammalian cells: From random release to selective secretion.The Journal of biological chemistry · 2026Review
- Long RNA profiles of endometrial extracellular vesicles provide new insights into the pathogenesis of ovarian endometriosis.BMC women's health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The extracellular matrix (ECM) is a dynamic and bioactive structure that provides both physical scaffolding and regulatory cues essential for tissue homeostasis, development, and disease. In parallel, extracellular vesicles (EVs) and their associated microRNAs (miRNAs) have emerged as critical mediators of intercellular communication, influencing diverse physiological and pathological processes. Increasing evidence highlights a reciprocal interplay between the ECM and EV-miRNAs: the ECM regulates EV biogenesis, miRNA sorting, transport, and uptake, while EV-miRNAs modulate ECM composition, remodeling, and mechanobiology. This bidirectional crosstalk has profound implications for tissue repair, fibrosis, and cancer progression, where aberrant ECM-EV-miRNA signaling contributes to matrix stiffening, immune modulation, angiogenesis, and metastasis. Recent findings demonstrate that ECM mechanics and biochemical factors dictate EV cargo profiles and delivery efficiency, whereas EV-miRNAs regulate the expression of ECM proteins and remodeling enzymes, thereby shaping the microenvironment. Despite significant advances, the molecular mechanisms underlying ECM-governed miRNA trafficking and EV-miRNA-driven ECM remodeling remain incompletely understood. A deeper mechanistic understanding of ECM-EV-miRNA interactions will not only shed light on fundamental aspects of microenvironmental signaling but also open new avenues for the development of ECM- and EV-based therapies for regenerative medicine and cancer treatment.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.